Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 7/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.55 |
| ▸ | BCR | P11274 | 4/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7944495 | 0.89 | HDAC1 (0.58) | HDAC1HDAC3HDAC2ALDH1A1KDM4E | |
| SCHEMBL2137319 | 0.88 | HDAC1 (0.76) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL29611891 | 0.80 | NPC1 (0.65) | ALDH1A1KDM4ESMN1; SMN2TDP1KDR | |
| SCHEMBL11192637 | 0.80 | NPC1 (0.65) | ALDH1A1KDM4ESMN1; SMN2TDP1KDR | |
| SCHEMBL15397972 | 0.80 | HDAC1 (0.69) | HDAC1HDAC3HDAC2 | |
| SCHEMBL2606722 | 0.79 | HDAC1 (0.59) | HDAC1HDAC3HDAC2SMN1; SMN2HDAC4 | |
| SCHEMBL4803395 | 0.78 | PDGFRA (0.87) | ABL1PDGFRBKDRBCRPDGFRA | |
| SCHEMBL7938657 | 0.77 | HDAC1 (0.60) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL1927373 | 0.77 | ABL1 (0.82) | ABL1PDGFRBKDRBCRPDGFRA | |
| SCHEMBL14082563 | 0.76 | MKNK1 (0.59) | ALDH1A1KDM4ESMN1; SMN2ABCB1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101147-A1 | INHIBITION OF HDAC2 TO PROMOTE MEMORY | THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL (US) | 2012-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101147-A1 | INHIBITION OF HDAC2 TO PROMOTE MEMORY | HDAC2, HDAC1, HDAC3 | HDAC1 2/4885HDAC3 3/4885HDAC2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.