Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2606701 | 0.89 | HDAC1 (0.58) | HDAC1HDAC3HDAC2ALDH1A1SMN1; SMN2 | |
| SCHEMBL2137319 | 0.88 | HDAC1 (0.76) | HDAC1HDAC3HDAC2 | |
| SCHEMBL7930500 | 0.86 | ABCB1 (0.61) | HDAC1HDAC3HDAC2ABCB1MKNK1 | |
| SCHEMBL11192637 | 0.80 | NPC1 (0.65) | ALDH1A1SMN1; SMN2KDM4ETDP1HTT | |
| SCHEMBL29611891 | 0.80 | NPC1 (0.65) | ALDH1A1SMN1; SMN2KDM4ETDP1HTT | |
| SCHEMBL15397972 | 0.77 | HDAC1 (0.69) | HDAC1HDAC3HDAC2 | |
| SCHEMBL7938657 | 0.77 | HDAC1 (0.60) | HDAC1HDAC3HDAC2 | |
| SCHEMBL4581935 | 0.76 | HDAC1 (0.79) | HDAC1HDAC3HDAC2 | |
| SCHEMBL11222723 | 0.75 | CNR1 (0.64) | ALDH1A1SMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL27860531 | 0.75 | HDAC1 (0.61) | HDAC1HDAC3HDAC2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010065117-A1 | INHIBITION OF HDAC2 TO PROMOTE MEMORY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-06-10 | — | — | WO | disclosed |