Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.33 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26067041 | 0.72 | TDO2 (0.37) | KDM4EALDH1A1LMNAMEN1MAPT | |
| SCHEMBL28456334 | 0.65 | NPC1 (0.47) | KDM4EALDH1A1MAPTGAAADORA2A | |
| SCHEMBL8388694 | 0.65 | — | — | |
| SCHEMBL30641570 | 0.64 | KDM4E (0.40) | KDM4EALDH1A1LMNAMEN1MAPT | |
| SCHEMBL13486503 | 0.64 | MAPT (0.45) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL9925944 | 0.63 | KDM4E (0.47) | KDM4EALDH1A1LMNAMEN1MAPT | |
| SCHEMBL4728473 | 0.63 | ALDH1A1 (0.38) | KDM4EALDH1A1LMNAMEN1MAPT | |
| SCHEMBL20016416 | 0.62 | SLC5A2 (0.41) | KDM4EALDH1A1LMNAMEN1MAPT | |
| SCHEMBL8297993 | 0.62 | KDM4E (0.46) | KDM4EALDH1A1MAPK1NPC1 | |
| SCHEMBL12481069 | 0.62 | MAPK1 (0.53) | KDM4EALDH1A1LMNAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023164233-A1 | (4-BENZO[D]OXAZOL-2-YL)-6,7-DIHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-5(4H)-YL)METHANONE DERIVATIVES AS MUTANT PAH STABILIZERS FOR THE TREATMENT OF PHENYLKETONURIA | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |