Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 2/20 | 0.40 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 6/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 5/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 5/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | AOC1 | P19801 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18844347 | 0.83 | MAP3K7 (0.38) | MAP3K7TAB1CYP2A6CYP2E1CYP2B6 | |
| SCHEMBL14649086 | 0.77 | MAP3K7 (0.56) | MAP3K7TAB1HSP90AB1IRAK4CHUK | |
| SCHEMBL9967152 | 0.70 | AKT1 (0.46) | HSP90AB1AKT1CHEK1IRAK4LRRK2 | |
| SCHEMBL14649091 | 0.69 | TRPA1 (0.44) | CYP2C19CYP2C9CYP3A4AKT1CHEK1 | |
| SCHEMBL312426 | 0.68 | CHEK1 (0.49) | MAP3K7TAB1HSP90AB1AKT1CHEK1 | |
| SCHEMBL2537071 | 0.67 | CHEK1 (0.61) | MAP3K7TAB1HSP90AB1AKT1CHEK1 | |
| SCHEMBL19306619 | 0.67 | BRAF (0.41) | MAP3K7TAB1HSP90AB1AKT1CHEK1 | |
| SCHEMBL310980 | 0.66 | CHEK1 (0.43) | MAP3K7TAB1HSP90AB1AKT1CHEK1 | |
| SCHEMBL26068312 | 0.66 | MAP3K7 (0.43) | MAP3K7TAB1AKT1JAK2JAK3 | |
| SCHEMBL19533409 | 0.65 | AKT1 (0.39) | HSP90AB1AKT1CHEK1IRAK4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230257414-A1 | NUCLEOTIDE ANALOGUES | FIRST-CITIZENS BANK & TRUST COMPANY | 2023-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230257414-A1 | NUCLEOTIDE ANALOGUES | ITPA, POLB, NUDT1 | MAP3K7 3559/4885TAB1 4527/4885CYP2A6 1541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.