Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 10/20 | 0.58 |
| ▸ | SOS1 | Q07889 | 10/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | FBP1 | P09467 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 2/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.55 |
| ▸ | PGK1 | P00558 | 2/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CCR4 | P51679 | 1/20 | 0.43 |
| ▸ | NRAS | P01111 | 1/20 | 0.43 |
| ▸ | HRAS | P01112 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26037134 | 0.90 | KRAS (0.49) | KRASSOS1EGFRFBP1PDE4A | |
| SCHEMBL7371454 | 0.85 | KRAS (0.57) | KRASSOS1EGFRFBP1PDE4A | |
| SCHEMBL11213054 | 0.81 | HTT (0.65) | EGFRPGK1ABCG2HTT | |
| SCHEMBL26070008 | 0.81 | EHMT2 (0.45) | KRASSOS1EGFRFBP1PDE4A | |
| SCHEMBL25571500 | 0.79 | SPIN1 (0.59) | — | |
| SCHEMBL12069892 | 0.79 | FBP1 (0.74) | KRASSOS1EGFRFBP1SLC2A1 | |
| SCHEMBL13335780 | 0.78 | PDE4A (0.57) | KRASSOS1EGFRFBP1PDE4A | |
| SCHEMBL28607756 | 0.77 | PDE4A (0.53) | KRASSOS1EGFRFBP1PDE4A | |
| SCHEMBL28605668 | 0.77 | PDE4A (0.53) | KRASSOS1EGFRFBP1PDE4A | |
| SCHEMBL23809903 | 0.77 | SYK (0.48) | EGFRDRD1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4234548-A1 | SUBSTITUTED BENZO OR PYRIDOPYRIMIDINE AMINE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | Suzhou Zelgen Biopharmaceutical Co., Ltd. (CN) | 2023-08-30 | — | — | EP | disclosed |