Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 2/20 | 0.41 |
| ▸ | PRKCG | P05129 | 2/20 | 0.41 |
| ▸ | PRKCB | P05771 | 2/20 | 0.41 |
| ▸ | PRKCA | P17252 | 2/20 | 0.41 |
| ▸ | PRKCH | P24723 | 2/20 | 0.41 |
| ▸ | PRKCI | P41743 | 2/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 8/20 | 0.39 |
| ▸ | LPAR3 | Q9UBY5 | 8/20 | 0.39 |
| ▸ | LPAR6 | P43657 | 6/20 | 0.39 |
| ▸ | LPAR4 | Q99677 | 6/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 6/20 | 0.39 |
| ▸ | LPAR2 | Q9HBW0 | 6/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14904899 | 0.92 | PRKD3 (0.41) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL4547611 | 0.92 | PRKD3 (0.41) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL14904902 | 0.92 | PRKD3 (0.41) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL8539607 | 0.88 | — | — | |
| SCHEMBL16580154 | 0.88 | — | — | |
| SCHEMBL18973933 | 0.84 | — | — | |
| SCHEMBL231223 | 0.84 | — | — | |
| SCHEMBL5832202 | 0.84 | — | — | |
| SCHEMBL16580160 | 0.84 | PRKD3 (0.36) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL18973894 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170349587-A1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | SHIONOGI & CO., LTD. (JP) | 2017-12-07 | — | — | US | disclosed |
| US-9758515-B2 | Substituted polycyclic carbamoyl pyridone derivative prodrug | SHIONOGI & CO., LTD. (JP) | 2017-09-12 | — | — | US | disclosed |
| US-20170217863-A1 | FLUORINATED TENSIDES | MERCK PATENT GMBH (DE) | 2017-08-03 | — | — | US | disclosed |
| US-20150111854-A1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | SHIONOGI & CO (JP) | 2015-04-23 | — | — | US | disclosed |
| US-8987441-B2 | Substituted polycyclic carbamoyl pyridone derivative prodrug | SHIONOGI & CO., LTD. (JP) | 2015-03-24 | — | — | US | disclosed |
| US-8158640-B2 | Tetrahydroquinoline derivatives and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-04-17 | — | — | US | disclosed |
| US-8158640-B2 | Tetrahydroquinoline derivatives and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-04-17 | — | — | US | disclosed |
| US-20110039828-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-02-17 | — | — | US | disclosed |
| US-20110039828-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-02-17 | — | — | US | disclosed |
| US-7872126-B2 | Tetrahydroquinoline derivatives and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-01-18 | — | — | US | disclosed |
| US-7872126-B2 | Tetrahydroquinoline derivatives and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-01-18 | — | — | US | disclosed |
| US-7462622-B2 | Pyrrolo[2, 3-d] pyrimidine derivatives as corticotropin releasing factor antagonists | GLAXO GROUP LIMITED (GB) | 2008-12-09 | — | — | US | disclosed |
| US-20070082896-A1 | Tetrahydroquinoline derivatives and a process for preparing the same | TANABE SEIYAKU CO., LTD. | 2007-04-12 | — | — | US | disclosed |
| US-20070082896-A1 | Tetrahydroquinoline derivatives and a process for preparing the same | TANABE SEIYAKU CO., LTD. | 2007-04-12 | — | — | US | disclosed |
| EP-0153640-A2 | Process for the preparation of 1,2,3,4,5,6,7,8-octahydro-anthrahydroquinones | BAYER AG (DE) | 1985-09-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111854-A1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | PREP, UNG, DPP4 | PRKD3 2954/4885PRKCG 3942/4885PRKCB 3613/4885 |
| US-20070082896-A1 | Tetrahydroquinoline derivatives and a process for preparing the same | CETP, MTTP, NPC1L1 | PRKD3 2334/4885PRKCG 2574/4885PRKCB 2499/4885 |
| US-20170217863-A1 | FLUORINATED TENSIDES | FLNA, KCNN3, FLNB | PRKD3 3678/4885PRKCG 1094/4885PRKCB 1838/4885 |
| US-20170349587-A1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | PREP, UNG, DPP4 | PRKD3 2954/4885PRKCG 3942/4885PRKCB 3613/4885 |
| US-20110039828-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME | CETP, MTTP, NPC1L1 | PRKD3 2334/4885PRKCG 2574/4885PRKCB 2499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.