SCHEMBL26071074

SCHEMBL26071074

N#C/C(NN)=C(/N)c1cccc(OCc2cscn2)c1

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
F2 P00734 8/20 0.37
GUSB P08236 1/20 0.36
PRSS1 P07477 6/20 0.36
NR4A2 P43354 1/20 0.34
CYSLTR1 Q9Y271 2/20 0.34
GPBAR1 Q8TDU6 1/20 0.34
NPC1 O15118 1/20 0.34
ALDH1A1 P00352 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26071042 0.82 SMN1; SMN2 (0.38) F2CYSLTR1NPC1ALDH1A1RAB9A
SCHEMBL26071009 0.81 NPC1 (0.39) F2GUSBPRSS1NPC1RAB9A
SCHEMBL26070929 0.81 F2 (0.46) F2
SCHEMBL26071076 0.79 PARP15 (0.48) F2GUSBNPC1ALDH1A1RAB9A
SCHEMBL26071082 0.78 ALOX15 (0.36) F2GUSBNPC1ALDH1A1RAB9A
SCHEMBL26071015 0.78 ACACB (0.39) F2GUSBCYSLTR1NPC1ALDH1A1
SCHEMBL26071058 0.78 GUSB (0.38) F2GUSBPRSS1CYSLTR1SMN1; SMN2
SCHEMBL26071011 0.78 NPC1 (0.42) F2GUSBPRSS1NPC1ALDH1A1
SCHEMBL26071073 0.76 SMPD1 (0.60) F2GUSBALDH1A1RAB9A
SCHEMBL26070590 0.76 NR4A2 (0.56) F2NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4219477-A1 CYANOTRIAZOLE COMPOUNDS Otsuka Pharmaceutical Co., Ltd. (JP) 2023-08-02 EP disclosed