SCHEMBL26074296

SCHEMBL26074296

Cc1ccnc(C(=O)Nc2cc(C(C)(C)C)c(C)cc2F)c1

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 1/20 0.46
FLT3 P36888 1/20 0.46
NPC1 O15118 5/20 0.41
RAB9A P51151 5/20 0.41
GAA P10253 2/20 0.41
MAPT P10636 1/20 0.41
NFKB1 P19838 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
PYGL P06737 1/20 0.41
PYGM P11217 1/20 0.41
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
CTSA P10619 1/20 0.38
ANO1 Q5XXA6 2/20 0.38
GRM5 P41594 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26074348 0.89 BRAF (0.40) NPC1RAB9AANO1
SCHEMBL26074299 0.89 FLT3 (0.45) CSF1RFLT3NPC1RAB9AGAA
SCHEMBL26074375 0.88 NPC1 (0.47) CSF1RFLT3NPC1RAB9AGAA
SCHEMBL26075548 0.87 BRAF (0.44) PYGLPYGMANO1
SCHEMBL26075764 0.87 RAF1 (0.43) ANO1
SCHEMBL26074277 0.86 CSF1R (0.47) CSF1RFLT3NPC1RAB9AGAA
SCHEMBL26075759 0.83 BRAF (0.47) ANO1
SCHEMBL26074350 0.80 LMNA (0.58) NPC1RAB9AMEN1KMT2A
SCHEMBL26074255 0.79 CSF1R (0.57) CSF1RFLT3NPC1RAB9AANO1
SCHEMBL26074469 0.78 KCNMA1 (0.48) NPC1RAB9AGAAMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230303570-A1 KINASE INHIBITORS AND USES THEREOF ABM THERAPEUTICS CORP (US) 2023-09-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230303570-A1 KINASE INHIBITORS AND USES THEREOF ERBB2, ERBB3, ERBB4 CSF1R 1249/4885FLT3 19/4885NPC1 4713/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.