SCHEMBL260768

SCHEMBL260768

Cc1cc([N+](=O)[O-])c(C)c([N+](=O)[O-])c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 1/20 0.67
TSHR P16473 6/20 0.60
CYP3A4 P08684 3/20 0.60
TDP1 Q9NUW8 3/20 0.58
CYP1A2 P05177 2/20 0.54
CCR6 P51684 1/20 0.53
KDM4E B2RXH2 1/20 0.52
GRIN2D O15399 1/20 0.50
GRIN3B O60391 1/20 0.50
GRIN1 Q05586 1/20 0.50
GRIN2A Q12879 1/20 0.50
GRIN2B Q13224 1/20 0.50
GRIN2C Q14957 1/20 0.50
GRIN3A Q8TCU5 1/20 0.50
ALDH1A1 P00352 4/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
MAPT P10636 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
SMN1; SMN2 Q16637 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzene SCHEMBL27490159 0.95 GPR35 (0.61) GPR35TSHRCYP3A4TDP1CYP1A2
SCHEMBL8977884 0.88 GPR35 (0.59) GPR35TSHRCYP3A4TDP1CYP1A2
SCHEMBL11113072 0.84 GPR35 (0.67) GPR35TSHRCYP3A4TDP1CYP1A2
SCHEMBL259813 0.84 TSHR (0.60) GPR35TSHRCYP3A4TDP1CYP1A2
SCHEMBL22968279 0.84 GPR35 (0.55) GPR35TSHRCYP3A4TDP1CYP1A2
SCHEMBL29434825 0.84 GPR35 (0.55) GPR35TSHRCYP3A4TDP1CYP1A2
SCHEMBL2957983 0.84 GPR35 (0.55) GPR35TSHRCYP3A4TDP1CYP1A2
Trinitrotoluene SCHEMBL20676 0.82 ALDH1A1 (0.61) GPR35TSHRCYP3A4TDP1CYP1A2
Trinitrotoluene SCHEMBL891182 0.82 ALDH1A1 (0.61) GPR35TSHRCYP3A4TDP1CYP1A2
SCHEMBL11802737 0.82 GPR35 (0.64) GPR35TSHRCYP3A4TDP1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111039790-B Synthesis method of 2, 6-dinitroterephthalic acid 浙江工业大学 2022-04-19 CN claimed
CN-111039790-A Synthesis method of 2, 6-dinitroterephthalic acid 浙江工业大学 2020-04-21 CN claimed
US-20230374214-A1 Mixed Aromatic Amine Monomers And Polymers Thereof ExxonMobil Technology and Engineering Company (US) 2023-11-23 US disclosed
US-20230374214-A1 Mixed Aromatic Amine Monomers And Polymers Thereof ExxonMobil Technology and Engineering Company (US) 2023-11-23 US disclosed
EP-4225728-A1 MIXED AROMATIC AMINE MONOMERS AND POLYMERS THEREOF ExxonMobil Technology and Engineering Company (US) 2023-08-16 EP disclosed
CN-116323548-A Mixed aromatic amine monomers and polymers thereof 埃克森美孚技术与工程公司 2023-06-23 CN disclosed
WO-2022082148-A1 MIXED AROMATIC AMINE MONOMERS AND POLYMERS THEREOF EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) 2022-04-21 WO disclosed
CN-111039790-B Synthesis method of 2, 6-dinitroterephthalic acid 浙江工业大学 2022-04-19 CN disclosed
CN-111039790-B Synthesis method of 2, 6-dinitroterephthalic acid 浙江工业大学 2022-04-19 CN disclosed
CN-107840826-B 1H-indazole derivatives and application thereof as IDO (intermediate bonded oxygen) inhibitor 西华大学 2021-07-09 CN disclosed
CN-107033087-B 1H-indazole-4-amine compounds and use thereof as IDO inhibitors 西华大学 2020-09-04 CN disclosed
US-4297501-A BY REACTING PRIMARY AMINES, CARBON MONOXIDE AND AN ORGANIC ALCOHOL IN THE PRESENCE OF OXYGEN AND A METAL CATALYST SYSTEM BAYER AKTIENGESELLSCHAFT (DE) 1981-10-27 US disclosed
EP-0016949-B1 PROCESS FOR PREPARING URETHANES BAYER AG (DE) 1981-10-14 EP disclosed
EP-0035752-A1 Process for the preparation of urethanes BAYER AG (DE) 1981-09-16 EP disclosed
EP-0005226-B1 PROCESS FOR THE MANUFACTURE OF URETHANES BAYER AG (DE) 1980-11-12 EP disclosed
EP-0016949-A1 Process for preparing urethanes BAYER AG (DE) 1980-10-15 EP disclosed
EP-0016346-A1 Process for preparing urethanes BAYER AG (DE) 1980-10-01 EP disclosed
EP-0014845-A1 Process for the preparation of urethanes BAYER AG (DE) 1980-09-03 EP disclosed
US-4219661-A FROM THE NITRO COMPOUND BAYER AKTIENGESELLSCHAFT (DE) 1980-08-26 US disclosed
EP-0005226-A1 Process for the manufacture of urethanes BAYER AG (DE) 1979-11-14 EP disclosed