Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.71 |
| ▸ | CDK1 | P06493 | 3/20 | 0.63 |
| ▸ | GSK3A | P49840 | 3/20 | 0.63 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.63 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.63 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.53 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.53 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | ROS1 | P08922 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13956701 | 0.86 | GSK3B (0.72) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL29381876 | 0.83 | GSK3B (1.00) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL29357223 | 0.83 | GSK3B (1.00) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL7255869 | 0.83 | GSK3B (0.71) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL5100148 | 0.83 | GSK3B (0.71) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL5100756 | 0.83 | GSK3B (0.68) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL4391839 | 0.83 | GSK3B (1.00) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL19322385 | 0.83 | GSK3B (0.70) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL4395874 | 0.82 | GSK3B (0.70) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL4393974 | 0.82 | GSK3B (0.75) | GSK3BCDK1GSK3ACCNB2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230313227-A1 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HEREDITARY ANGIOEDEMA | ORCHARD THERAPEUTICS EUROPE LTD (GB) | 2023-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230313227-A1 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HEREDITARY ANGIOEDEMA | SERPINH1, SERPINB1, SERPINB6 | GSK3B 3744/4885CDK1 3108/4885GSK3A 3659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.