Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13047495 | 1.00 | NOTUM (0.43) | NOTUMABHD6HSD11B1KMT2AMEN1 | |
| SCHEMBL2608452 | 0.90 | NOTUM (0.41) | NOTUMABHD6HSD11B1KMT2AMEN1 | |
| SCHEMBL13047498 | 0.90 | NOTUM (0.41) | NOTUMABHD6HSD11B1KMT2AMEN1 | |
| SCHEMBL2608464 | 0.84 | NOTUM (0.47) | NOTUMABHD6HSD11B1KMT2AMEN1 | |
| SCHEMBL13223170 | 0.84 | NOTUM (0.52) | NOTUMABHD6HSD11B1KMT2AMEN1 | |
| SCHEMBL2102123 | 0.82 | NOTUM (0.44) | NOTUMABHD6HSD11B1KMT2AMEN1 | |
| SCHEMBL3739001 | 0.80 | PRMT5 (0.48) | NOTUMABHD6TP53PRMT5WDR77 | |
| SCHEMBL2100310 | 0.80 | PRMT5 (0.48) | NOTUMABHD6TP53PRMT5WDR77 | |
| SCHEMBL8278742 | 0.78 | NOTUM (0.50) | NOTUMABHD6HSD11B1KMT2AMEN1 | |
| SCHEMBL7856938 | 0.78 | ABHD6 (0.43) | NOTUMABHD6HSD11B1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163693-B2 | Urea-containing peptides as inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20090082261-A1 | UREA-CONTAINING PEPTIDES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2009-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082261-A1 | UREA-CONTAINING PEPTIDES AS INHIBITORS OF VIRAL REPLICATION | VIP, SLC14A1, RPL35 | NOTUM 3415/4885ABHD6 2763/4885HSD11B1 4074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.