Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.41 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 4/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30378526 | 1.00 | MAP3K14 (0.41) | MAP3K14TTBK1RAF1CCR5HSD17B10 | |
| SCHEMBL24312573 | 0.85 | MAP3K14 (0.41) | MAP3K14TTBK1RAF1ALDH1A1MAPT | |
| SCHEMBL29567366 | 0.85 | MAP3K14 (0.41) | MAP3K14TTBK1RAF1ALDH1A1MAPT | |
| SCHEMBL24318087 | 0.83 | RAF1 (0.41) | RAF1CCR5KMT2AAKR1C3ALDH1A1 | |
| SCHEMBL30378778 | 0.82 | CCR5 (0.39) | RAF1CCR5KMT2AAKR1C3ALDH1A1 | |
| SCHEMBL26087675 | 0.82 | CCR5 (0.39) | RAF1CCR5KMT2AAKR1C3ALDH1A1 | |
| SCHEMBL16094628 | 0.77 | MAPK1 (0.44) | RAF1CCR5HSD17B10KMT2AALDH1A1 | |
| SCHEMBL30378293 | 0.77 | CCR5 (0.41) | RAF1CCR5HSD17B10KMT2AAKR1C3 | |
| SCHEMBL26089341 | 0.77 | CCR5 (0.41) | RAF1CCR5HSD17B10KMT2AAKR1C3 | |
| SCHEMBL16094963 | 0.72 | CCR5 (0.43) | CCR5HSD17B10KMT2AAKR1C3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023070053-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| WO-2023070053-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2023-04-27 | — | — | WO | disclosed |