Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26089341 | 1.00 | CCR5 (0.41) | CCR5RAF1NPC1RAB9AMAPK1 | |
| SCHEMBL16094628 | 0.85 | MAPK1 (0.44) | CCR5RAF1NPC1MAPK1ALDH1A1 | |
| SCHEMBL24318087 | 0.82 | RAF1 (0.41) | CCR5RAF1NPC1RAB9AMAPK1 | |
| SCHEMBL30378747 | 0.82 | MAPK1 (0.41) | RAF1MAPK1MAPTTSHRKDM4E | |
| SCHEMBL26090535 | 0.82 | MAPK1 (0.41) | RAF1MAPK1MAPTTSHRKDM4E | |
| SCHEMBL26087675 | 0.81 | CCR5 (0.39) | CCR5RAF1NPC1RAB9AMAPK1 | |
| SCHEMBL30378778 | 0.81 | CCR5 (0.39) | CCR5RAF1NPC1RAB9AMAPK1 | |
| SCHEMBL30378526 | 0.77 | MAP3K14 (0.41) | CCR5RAF1ALDH1A1AKR1C3MAPT | |
| SCHEMBL26089350 | 0.77 | MAP3K14 (0.41) | CCR5RAF1ALDH1A1AKR1C3MAPT | |
| SCHEMBL16094760 | 0.76 | CCR5 (0.43) | CCR5MAPK1ALDH1A1AKR1C3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023070053-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2023-04-27 | — | — | WO | disclosed |