Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 9/20 | 0.58 |
| ▸ | CHKA known ✓ | P35790 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.78 |
| ▸ | BCHE | P06276 | 9/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL30903821 | 1.00 | HTT (0.78) | HTTBCHEACHECHKAMEN1 | |
| SCHEMBL12533274 | 0.97 | HTT (0.82) | HTTBCHEACHECHKAMEN1 | |
| SCHEMBL4403595 | 0.97 | HTT (0.82) | HTTBCHEACHECHKAMEN1 | |
| Bromide SCHEMBL26090896 | 0.95 | HTT (0.78) | HTTBCHEACHECHKAMEN1 | |
| SCHEMBL12533280 | 0.95 | HTT (0.77) | HTTBCHEACHECHKAMEN1 | |
| Iodide SCHEMBL1932275 | 0.92 | HTT (0.74) | HTTBCHEACHEMEN1TP53 | |
| Bromide SCHEMBL9362504 | 0.91 | HTT (0.96) | HTTACHEMEN1TP53CYP1A2 | |
| Miripirium SCHEMBL10323639 | 0.91 | HTT (0.96) | HTTACHEMEN1TP53CYP1A2 | |
| Bromide SCHEMBL1502820 | 0.91 | HTT (0.96) | HTTACHEMEN1TP53CYP1A2 | |
| Bromide SCHEMBL1502789 | 0.91 | HTT (0.96) | HTTACHEMEN1TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4419206-B1 | COMPOUNDS FOR THE TREATMENT OF MALARIA | FUNDACIO INST DE BIOENGINYERIA DE CATALUNYA (ES) | 2025-09-17 | — | — | EP | disclosed |
| US-20240415825-A1 | COMPOUNDS FOR THE TREATMENT OF MALARIA | Fundación Privada Instituto De Salud Global Barcelona (ES) | 2024-12-19 | — | — | US | disclosed |
| EP-4419206-A1 | COMPOUNDS FOR THE TREATMENT OF MALARIA | Fundacio Institut de Bioenginyeria de Catalunya (ES) | 2024-08-28 | — | — | EP | disclosed |
| CN-118475559-A | Compounds for malaria treatment | 加泰罗尼亚生物工程基金会研究所 | 2024-08-09 | — | — | CN | disclosed |
| WO-2023067170-A1 | COMPOUNDS FOR THE TREATMENT OF MALARIA | FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA (ES) | 2023-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240415825-A1 | COMPOUNDS FOR THE TREATMENT OF MALARIA | ABAT, GLS2, CPS1 | ACHE 148/4885CHKA 698/4885HTT 1730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.