Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 8/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 8/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12533280 | 0.97 | HTT (0.77) | HTTKDM4ENPC1LMNARAB9A | |
| SCHEMBL12533274 | 0.94 | HTT (0.82) | HTTKDM4ENPC1LMNARAB9A | |
| SCHEMBL4403595 | 0.94 | HTT (0.82) | HTTKDM4ENPC1LMNARAB9A | |
| Bromide SCHEMBL30903821 | 0.92 | HTT (0.78) | HTTBCHEACHEMEN1TP53 | |
| SCHEMBL18234751 | 0.92 | HTT (0.70) | HTTKDM4ENPC1LMNARAB9A | |
| Iodide SCHEMBL1502813 | 0.89 | HTT (0.96) | HTTKDM4ENPC1LMNARAB9A | |
| Iodide SCHEMBL1502868 | 0.89 | HTT (0.96) | HTTKDM4ENPC1LMNARAB9A | |
| Iodide SCHEMBL1502898 | 0.89 | HTT (0.96) | HTTKDM4ENPC1LMNARAB9A | |
| Iodide SCHEMBL10323429 | 0.89 | HTT (0.96) | HTTKDM4ENPC1LMNARAB9A | |
| Iodide SCHEMBL9271857 | 0.89 | HTT (0.96) | HTTKDM4ENPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240360318-A1 | DYES FOR ANALYSIS OF PROTEIN AGGREGATION | ENZO BIOCHEM, INC. (US) | 2024-10-31 | — | — | US | disclosed |
| US-20210009809-A1 | DYES FOR ANALYSIS OF PROTEIN AGGREGATION | ENZO LIFE SCIENCES, INC. (US) | 2021-01-14 | — | — | US | disclosed |
| EP-2507319-B1 | DYES FOR ANALYSIS OF PROTEIN AGGREGATION | ENZO LIFE SCIENCES INC (US) | 2019-08-28 | — | — | EP | disclosed |
| US-20180273759-A1 | DYES FOR ANALYSIS OF PROTEIN AGGREGATION | ENZO LIFE SCIENCES, INC. (US) | 2018-09-27 | — | — | US | disclosed |
| US-9932479-B2 | Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications | ENZO BIOCHEM, INC. (US) | 2018-04-03 | — | — | US | disclosed |
| US-20160280921-A1 | DYES FOR ANALYSIS OF PROTEIN AGGREGATION | ENZO LIFE SCIENCES, INC. (US) | 2016-09-29 | — | — | US | disclosed |
| US-20150376411-A1 | NOVEL DYES AND COMPOSITIONS, AND PROCESSES FOR USING SAME IN ANALYSIS OF PROTEIN AGGREGATION AND OTHER APPLICATIONS | ENZO BIOCHEM, INC. (US) | 2015-12-31 | — | — | US | disclosed |
| US-9133343-B2 | Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications | ENZO BIOCHEM, INC. (US) | 2015-09-15 | — | — | US | disclosed |
| US-20130137112-A1 | DYES FOR ANALYSIS OF PROTEIN AGGREGATION | ENZO LIFE SCIENCES, INC. | 2013-05-30 | — | — | US | disclosed |
| EP-2507319-A2 | DYES FOR ANALYSIS OF PROTEIN AGGREGATION | Enzo Life Sciences, Inc. (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011065980-A2 | DYES FOR ANALYSIS OF PROTEIN AGGREGATION | ENZO LIFE SCIENCES, INC. (US) | 2011-06-03 | — | — | WO | disclosed |
| US-20110130305-A1 | Novel dyes and compositions, and processes for using same in analysis of protein aggregation and other applications | ENZO LIFE SCIENCES, INC. | 2011-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009809-A1 | DYES FOR ANALYSIS OF PROTEIN AGGREGATION | CRYAA, CRYAB, HSPH1 | ACHE 255/4885HTT 36/4885KDM4E 4633/4885 |
| US-20130137112-A1 | DYES FOR ANALYSIS OF PROTEIN AGGREGATION | CRYAA, CRYAB, HSPH1 | ACHE 255/4885HTT 36/4885KDM4E 4633/4885 |
| US-20240360318-A1 | DYES FOR ANALYSIS OF PROTEIN AGGREGATION | CRYAA, CRYAB, HSPH1 | ACHE 255/4885HTT 36/4885KDM4E 4633/4885 |
| US-20110130305-A1 | Novel dyes and compositions, and processes for using same in analysis of protein aggregation and other applications | APP, CRYAA, CRYAB | ACHE 679/4885HTT 30/4885KDM4E 4352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.