Stilonium

Stilonium

SCHEMBL26104

CC[N+](CC)(CC)CCOc1ccc(/C=C/c2ccccc2)cc1.[I-]

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG

The experimentally established mechanism targets of Stilonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 19/20 1.00
CHRNB4 P30926 10/20 1.00
CHRNA3 P32297 10/20 1.00
CHRNA10 Q9GZZ6 5/20 1.00
CHRNA9 Q9UGM1 5/20 1.00
CHRNB2 P17787 4/20 1.00
CHRNA4 P43681 4/20 1.00
APOBEC3A P31941 1/20 1.00
CTDSP1 Q9GZU7 1/20 1.00
APOBEC3G Q9HC16 1/20 1.00
MAPT P10636 1/20 0.97
KDM4E B2RXH2 1/20 0.97
MEN1 O00255 1/20 0.97
ALDH1A1 P00352 1/20 0.97
TP53 P04637 1/20 0.97
CYP1A2 P05177 1/20 0.97
CYP2D6 P10635 1/20 0.97
HPGD P15428 1/20 0.97
ALOX15 P16050 1/20 0.97
KMT2A Q03164 1/20 0.97

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Stilonium SCHEMBL26105 1.00 CHRNA7 (1.00) CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9
Stilonium SCHEMBL10197132 0.98 CHRNA7 (1.00) CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9
SCHEMBL13385235 0.83 CHRNA7 (1.00) CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9
Hydrochloric Acid SCHEMBL11423649 0.81 CHRNA7 (0.96) CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9
SCHEMBL1618632 0.80 RELA (0.72) CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9
SCHEMBL5741015 0.80 RELA (0.72) CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9
SCHEMBL80814 0.76 CHRNA7 (0.72) CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9
SCHEMBL436231 0.76 RELA (1.00) CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9
SCHEMBL5496245 0.76 RELA (1.00) CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9
SCHEMBL5739190 0.76 CHRNA7 (0.68) CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 764 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112237631-B Use of acetylcholine pathway modulators in the treatment of cancer 清华大学 2022-03-04 CN claimed
US-10383510-B2 Implant with high vapor pressure medium SOLACE THERAPEUTICS, INC. (US) 2019-08-20 US claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
EP-2367503-A1 IMPLANT WITH HIGH VAPOR PRESSURE MEDIUM AttenueX Technologies, Inc. (US) 2011-09-28 EP claimed
US-20100222802-A1 IMPLANT WITH HIGH VAPOR PRESSURE MEDIUM ATTENUEX TECHNOLOGIES, INC. (US) 2010-09-02 US claimed
WO-2010068467-A1 IMPLANT WITH HIGH VAPOR PRESSURE MEDIUM ATTENUEX TECHNOLOGIES, INC. (US) 2010-06-17 WO claimed
EP-1879578-A4 METHODS AND COMPOSITIONS FOR THE TREATMENT OF URINARY INCONTINENCE DOV PHARMACEUTICAL INC (US) 2009-05-13 EP claimed
EP-1879578-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF URINARY INCONTINENCE DOV Pharmaceutical Inc. (US) 2008-01-23 EP claimed
WO-2006102029-A9 METHODS AND COMPOSITIONS FOR THE TREATMENT OF URINARY INCONTINENCE DOV PHARMACEUTICAL INC (US) 2006-12-07 WO claimed
WO-2006102029-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF URINARY INCONTINENCE DOV PHARMACEUTICAL, INC. (US) 2006-09-28 WO claimed
US-20060024365-A1 Novel dosage form VAYA NAVIN 2006-02-02 US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
EP-4168092-B1 BALLOON CATHETER WITH PRECISION DRUG-ELUTING CAPABILITY BARD INC C R (US) 2026-05-27 EP disclosed
EP-0737066-A1 TRANSDERMAL DEVICE CONTAINING POLYVINYLPYRROLIDONE AS SOLUBILITY ENHANCER NOVEN PHARMACEUTICALS, INC. (US) 1996-10-16 EP disclosed
WO-1995018603-A1 TRANSDERMAL DEVICE CONTAINING POLYVINYLPYRROLIDONE AS SOLUBILITY ENHANCER NOVEN PHARMACEUTICALS, INC. (US) 1995-07-13 WO disclosed