Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.37 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14268085 | 0.83 | TUBB1 (0.41) | SLC6A4SLC6A2SLC6A3ALDH1A1PDGFRB | |
| SCHEMBL1827513 | 0.82 | ALDH1A1 (0.39) | ALDH1A1PDGFRBPDGFRAHTTP2RX3 | |
| SCHEMBL1054720 | 0.79 | ALDH1A1 (0.46) | SLC6A4SLC6A2SLC6A3ALDH1A1PDGFRB | |
| SCHEMBL8118182 | 0.78 | DRD1 (0.39) | ALDH1A1PDGFRBPDGFRAHTTP2RX3 | |
| SCHEMBL4128579 | 0.77 | UHRF1 (0.43) | SLC6A4SLC6A2SLC6A3ALDH1A1PDGFRB | |
| SCHEMBL2117006 | 0.77 | ALOX5AP (0.42) | ALDH1A1PDGFRBPDGFRAP2RX3P2RX2 | |
| SCHEMBL2117484 | 0.77 | KCNQ3 (0.41) | SLC6A4ALDH1A1PDGFRBPDGFRAKCNH2 | |
| SCHEMBL21807891 | 0.77 | PDGFRB (0.36) | ALDH1A1PDGFRBPDGFRAHTTP2RX3 | |
| SCHEMBL29698232 | 0.77 | PDGFRB (0.36) | ALDH1A1PDGFRBPDGFRAHTTP2RX3 | |
| SCHEMBL29972903 | 0.77 | KCNQ3 (0.41) | SLC6A4ALDH1A1PDGFRBPDGFRAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268848-B2 | Cyclopropane compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-09-18 | — | — | US | disclosed |
| US-20120095031-A1 | CYCLOPROPANE COMPOUND | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095031-A1 | CYCLOPROPANE COMPOUND | HCRTR1, HCRTR2, CNR1 | SLC6A4 370/4885SLC6A2 331/4885SLC6A3 235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.