Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | KIF5B | P33176 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21807891 | 1.00 | PDGFRB (0.36) | PDGFRBPDGFRAALDH1A1PIK3CAMTOR | |
| SCHEMBL27038119 | 0.83 | PDGFRB (0.38) | PDGFRBPDGFRAALDH1A1PIK3CAMTOR | |
| SCHEMBL8118182 | 0.81 | DRD1 (0.39) | PDGFRBPDGFRAALDH1A1HTTP2RX3 | |
| SCHEMBL23976562 | 0.80 | ALDH1A1 (0.44) | PDGFRBPDGFRAALDH1A1AXLGAA | |
| SCHEMBL1827513 | 0.80 | ALDH1A1 (0.39) | PDGFRBPDGFRAALDH1A1HTTP2RX3 | |
| SCHEMBL22978591 | 0.80 | SMN1; SMN2 (0.38) | ALDH1A1HTTKDM1AGAAL3MBTL1 | |
| SCHEMBL15933053 | 0.78 | AXL (0.43) | ALDH1A1P2RX3P2RX2AXLPOLB | |
| SCHEMBL18348256 | 0.77 | NQO2 (0.37) | PDGFRBPDGFRAALDH1A1P2RX3P2RX2 | |
| SCHEMBL2610403 | 0.77 | SLC6A4 (0.41) | PDGFRBPDGFRAALDH1A1HTTP2RX3 | |
| SCHEMBL24509373 | 0.76 | GRIN1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010334-A1 | HETEROCYCLIC WDR5 INHIBITORS AS ANTI-CANCER COMPOUNDS | Novartis AG (CH) | 2022-06-15 | — | — | EP | disclosed |