Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26106571 | 0.86 | TRPV1 (0.41) | PDE10AHSD11B1SLC6A7TRPA1TRPV1 | |
| SCHEMBL26107543 | 0.82 | TRPV1 (0.46) | NPSR1LMNAKDM4EMAPTHTT | |
| SCHEMBL26106568 | 0.78 | SLC6A7 (0.51) | NPSR1LMNAKDM4EMAPTHTT | |
| SCHEMBL30591895 | 0.78 | SLC6A7 (0.51) | NPSR1LMNAKDM4EMAPTHTT | |
| Hydrochloric Acid SCHEMBL3322312 | 0.76 | MAPT (0.57) | PDE10ANPSR1KDM4EMAPTALDH1A1 | |
| SCHEMBL26107483 | 0.74 | TRPV1 (0.46) | TRPV1 | |
| SCHEMBL26105650 | 0.74 | PDE10A (0.42) | PDE10ATRPA1TRPV1 | |
| SCHEMBL26105942 | 0.73 | SMO (0.41) | HSD11B1TRPV1 | |
| SCHEMBL26103628 | 0.72 | CNR2 (0.45) | KDM4EMAPTHTTHPGDGAA | |
| SCHEMBL26107660 | 0.72 | TRPV1 (0.49) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023183768-A2 | SMALL MOLECULE INHIBITORS OF TEA DOMAIN FAMILY MEMBERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-09-28 | — | — | WO | disclosed |