Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26105650 | 0.87 | PDE10A (0.42) | PDE10ATRPV1 | |
| SCHEMBL26108261 | 0.86 | PDE10A (0.35) | PDE10A | |
| SCHEMBL26105644 | 0.84 | PDE10A (0.41) | PDE10ATRPV1 | |
| SCHEMBL26105333 | 0.84 | PDE10A (0.37) | PDE10ASCN9ASCN10A | |
| SCHEMBL26107789 | 0.82 | SCN9A (0.35) | PDE10ASCN9A | |
| SCHEMBL26107722 | 0.80 | HRH4 (0.44) | PDE10A | |
| SCHEMBL26106840 | 0.80 | PDE10A (0.41) | PDE10A | |
| SCHEMBL26103135 | 0.80 | PDE10A (0.41) | PDE10ATRPV1 | |
| SCHEMBL30591660 | 0.79 | TRPV1 (0.41) | PDE10ATRPV1SCN9ASCN10A | |
| SCHEMBL26104463 | 0.79 | TRPV1 (0.41) | PDE10ATRPV1SCN9ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023183768-A2 | SMALL MOLECULE INHIBITORS OF TEA DOMAIN FAMILY MEMBERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-09-28 | — | — | WO | disclosed |