SCHEMBL261089

SCHEMBL261089

O=C1c2ccc(Oc3ccc4c(c3)C(=O)N(Cc3ccccc3)C4=O)cc2C(=O)N1Cc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.61
MEN1 O00255 2/20 0.61
HPGD P15428 1/20 0.61
TDP1 Q9NUW8 2/20 0.60
CASP3 P42574 2/20 0.58
KDM4E B2RXH2 2/20 0.55
ALDH1A1 P00352 2/20 0.55
HTT P42858 1/20 0.55
MAPK1 P28482 1/20 0.54
HSD17B10 Q99714 1/20 0.54
LPAR1 Q92633 1/20 0.54
LPAR3 Q9UBY5 1/20 0.54
MMP13 P45452 1/20 0.53
HDAC3 O15379 1/20 0.52
HDAC4 P56524 1/20 0.52
HDAC1 Q13547 1/20 0.52
HDAC7 Q8WUI4 1/20 0.52
HDAC2 Q92769 1/20 0.52
HDAC10 Q969S8 1/20 0.52
HDAC11 Q96DB2 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20425210 0.97 MEN1 (0.58) KMT2AMEN1HPGDTDP1CASP3
SCHEMBL31667726 0.88 POLB (0.50) KMT2AMEN1HPGDTDP1LPAR1
SCHEMBL4728227 0.88 TDP1 (0.66) KMT2AMEN1HPGDTDP1CASP3
SCHEMBL31667175 0.87 BRD4 (0.56) KMT2AMEN1HPGDTDP1CASP3
SCHEMBL2570381 0.83 CASP3 (0.63) KMT2AMEN1HPGDCASP3KDM4E
SCHEMBL15923547 0.83 KMT2A (0.60) KMT2AMEN1HPGDTDP1CASP3
SCHEMBL17946340 0.81 KMT2A (0.67) KMT2AMEN1HPGDCASP3KDM4E
SCHEMBL14392383 0.81 NPSR1 (0.69) KMT2AMEN1HPGDCASP3KDM4E
SCHEMBL20806112 0.81 TDP1 (0.50) KMT2AMEN1HPGDTDP1CASP3
SCHEMBL326305 0.80 CASP3 (0.85) KMT2AMEN1HPGDCASP3KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2097375-B1 METHOD FOR PURIFYING BISIMIDES SABIC INNOVATIVE PLASTICS IP (NL) 2013-04-24 EP disclosed
EP-2089348-B1 METHOD FOR MAKING POLYETHERIMIDES SABIC INNOVATIVE PLASTICS IP (NL) 2013-02-20 EP disclosed
US-8134016-B2 Method for purifying dianhydrides SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-03-13 US disclosed
EP-2094691-B1 METHOD FOR PURIFYING DIANHYDRIDES SABIC INNOVATIVE PLASTICS IP (NL) 2011-05-25 EP disclosed
EP-2097375-A1 METHOD FOR PURIFYING BISIMIDES Sabic Innovative Plastics IP B.V. (NL) 2009-09-09 EP disclosed
EP-2094691-A1 METHOD FOR PURIFYING DIANHYDRIDES Sabic Innovative Plastics IP B.V. (NL) 2009-09-02 EP disclosed
EP-2089348-A1 METHOD FOR MAKING POLYETHERIMIDES Sabic Innovative Plastics IP B.V. (NL) 2009-08-19 EP disclosed
US-20080319210-A1 METHOD FOR PURIFYING DIANHYDRIDES SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2008-12-25 US disclosed
US-7446214-B2 Method for purifying oxybisphthalic anhydrides SABIC INNOVATIVE PLASTICS IP B.V. (US) 2008-11-04 US disclosed
US-7411032-B2 Method for making polyetherimides SABIC INNOVATIVE PLASTICS IP B.V. (US) 2008-08-12 US disclosed
US-7408070-B2 Method for purifying bisimides SABIC INNOVATIVE PLASTICS IP B.V. (US) 2008-08-05 US disclosed
WO-2008063206-A1 METHOD FOR MAKING POLYETHERIMIDES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-05-29 WO disclosed
WO-2008063208-A1 METHOD FOR PURIFYING BISIMIDES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-05-29 WO disclosed
WO-2008063207-A1 METHOD FOR PURIFYING DIANHYDRIDES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-05-29 WO disclosed
US-20070073066-A1 Method for purifying dianhydrides GENERAL ELECTRIC COMPANY (US) 2007-03-29 US disclosed
US-20070073035-A1 Method for making polyetherimides GENERAL ELECTRIC COMPANY (US) 2007-03-29 US disclosed
US-20070073063-A1 Method for purifying bisimides GENERAL ELECTRIC COMPANY (US) 2007-03-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070073063-A1 Method for purifying bisimides FHIT, PBRM1, TNS4 KMT2A 363/4885MEN1 1143/4885HPGD 2753/4885
US-20080319210-A1 METHOD FOR PURIFYING DIANHYDRIDES AQP4, TRRAP, GYPA KMT2A 266/4885MEN1 3302/4885HPGD 1197/4885
US-20070073066-A1 Method for purifying dianhydrides AQP4, TRRAP, GYPA KMT2A 266/4885MEN1 3302/4885HPGD 1197/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.