Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30546398 | 0.83 | HCAR3 (0.34) | HCAR3GBA1USP30MMP2AOC3 | |
| SCHEMBL14484887 | 0.81 | GFER (0.47) | HCAR3GBA1USP30AOC3KDM4E | |
| SCHEMBL23073628 | 0.81 | HCAR3 (0.45) | HCAR3GBA1AOC3KDM4EALDH1A1 | |
| SCHEMBL8750801 | 0.80 | GBA1 (0.55) | HCAR3GBA1USP30AOC3KDM4E | |
| SCHEMBL23073650 | 0.79 | GBA1 (0.41) | HCAR3GBA1USP30AOC3KDM4E | |
| SCHEMBL14484955 | 0.78 | GBA1 (0.42) | HCAR3GBA1USP30AOC3KDM4E | |
| SCHEMBL26124987 | 0.76 | GBA1 (0.41) | HCAR3GBA1USP30AOC3KDM4E | |
| SCHEMBL26127470 | 0.76 | HCAR3 (0.35) | HCAR3GBA1USP30MMP2AOC3 | |
| SCHEMBL26127469 | 0.76 | MMP2 (0.37) | HCAR3GBA1USP30MMP2AOC3 | |
| SCHEMBL26296938 | 0.74 | HCAR3 (0.51) | HCAR3GBA1AOC3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192989-A2 | PHTHALAZINONE COMPOUNDS AS PARP7 INHIBITORS | AZKARRA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |