SCHEMBL26125223

SCHEMBL26125223

CCOC(=O)CN1C2CC1CN(c1ncc(C(F)(F)F)cn1)C2

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 1/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ TIPARP Q7Z3E1 1/20 0.41
▸ ACACB O00763 1/20 0.41
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ CHRM4 P08173 6/20 0.40
▸ SLC6A9 P48067 1/20 0.39
▸ PPARG P37231 2/20 0.39
▸ POLB P06746 2/20 0.39
▸ PPARD Q03181 1/20 0.38
▸ PPARA Q07869 1/20 0.38
▸ CHRM2 P08172 1/20 0.38
▸ HCRTR2 O43614 2/20 0.37
▸ TRPM2 O94759 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26124703 0.93 HPGD (0.42) HPGDSMN1; SMN2ACACBMEN1KMT2A
SCHEMBL26125507 0.83 TIPARP (0.43) TIPARPACACBCHRM4SLC6A9PPARG
SCHEMBL30286299 0.82 TIPARP (0.42) TIPARPACACBCHRM4SLC6A9CHRM2
SCHEMBL31647906 0.81 SMN1; SMN2 (0.46) HPGDSMN1; SMN2ACACBMEN1KMT2A
SCHEMBL26122829 0.80 ACACB (0.43) HPGDSMN1; SMN2TIPARPACACBMEN1
SCHEMBL26125453 0.76 ACACB (0.42) TIPARPACACBSLC6A9CHRM2
SCHEMBL30286308 0.75 ACACB (0.42) TIPARPACACBCHRM4SLC6A9CHRM2
SCHEMBL26123468 0.74 GPR119 (0.48) HPGDSMN1; SMN2TIPARPMEN1KMT2A
SCHEMBL27173051 0.74 TIPARP (0.47) TIPARPACACBCHRM4SLC6A9PPARG
SCHEMBL25309274 0.73 GPR119 (0.52) TIPARPACACBCHRM4PPARGPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240336596-A1 PARP7 INHIBITOR AND USE THEREOF NOVOSTAR PHARMACEUTICALS, LTD. (CN) 2024-10-10 — — US disclosed
EP-4338737-A1 PARP7 INHIBITOR AND USE THEREOF Novostar Pharmaceuticals, Ltd. (CN) 2024-03-20 — — EP disclosed
WO-2023185073-A1 PARP7 INHIBITOR AND USE THEREOF 诺沃斯达药业(上海)有限公司 2023-10-05 — — WO disclosed
WO-2023185073-A1 PARP7 INHIBITOR AND USE THEREOF 诺沃斯达药业(上海)有限公司 2023-10-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240336596-A1 PARP7 INHIBITOR AND USE THEREOF PARP1, PARP3, PARP11 HPGD 335/4885SMN1; SMN2 1592/4885TIPARP 54/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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