Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 5/20 | 0.49 |
| ▸ | BLM | P54132 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | ALPL | P05186 | 2/20 | 0.49 |
| ▸ | ALPI | P09923 | 2/20 | 0.49 |
| ▸ | ALPG | P10696 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26135297 | 1.00 | GAA (0.65) | GAAMEN1KMT2ALMNAPOLB | |
| SCHEMBL26135296 | 1.00 | GAA (0.65) | GAAMEN1KMT2ALMNAPOLB | |
| SCHEMBL26134880 | 0.84 | LMNA (0.47) | GAAMEN1KMT2ALMNAPOLB | |
| SCHEMBL26134884 | 0.84 | LMNA (0.47) | GAAMEN1KMT2ALMNAPOLB | |
| SCHEMBL26135603 | 0.84 | LMNA (0.47) | GAAMEN1KMT2ALMNAPOLB | |
| SCHEMBL1132163 | 0.79 | MEN1 (0.72) | GAAMEN1KMT2ALMNAPOLB | |
| SCHEMBL1132161 | 0.79 | MEN1 (0.72) | GAAMEN1KMT2ALMNAPOLB | |
| SCHEMBL24784904 | 0.79 | MEN1 (1.00) | GAAMEN1KMT2ALMNAPOLB | |
| SCHEMBL30548101 | 0.79 | MEN1 (1.00) | GAAMEN1KMT2ALMNAPOLB | |
| SCHEMBL19736310 | 0.79 | MEN1 (1.00) | GAAMEN1KMT2ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250214982-A1 | COMPOUNDS USABLE AS MODULATORS OF PERK ACTIVITY | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2025-07-03 | — | — | US | disclosed |
| EP-4499615-A1 | COMPOUNDS USABLE AS MODULATORS OF PERK ACTIVITY | Ramot at Tel-Aviv University Ltd. (IL) | 2025-02-05 | — | — | EP | disclosed |
| WO-2023187783-A1 | COMPOUNDS USABLE AS MODULATORS OF PERK ACTIVITY | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2023-10-05 | — | — | WO | disclosed |
| WO-2023187783-A1 | COMPOUNDS USABLE AS MODULATORS OF PERK ACTIVITY | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2023-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250214982-A1 | COMPOUNDS USABLE AS MODULATORS OF PERK ACTIVITY | ATF4, ERN1, ERN2 | GAA 494/4885MEN1 2680/4885KMT2A 4213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.