Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thyroxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 11/20 | 1.00 |
| ▸ | THRA known ✓ | P10827 | 7/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | PPARG | P37231 | 5/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | USP2 | O75604 | 3/20 | 1.00 |
| ▸ | TTR | P02766 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | RXRA | P19793 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dextrothyroxine SCHEMBL30885760 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Thyroxine SCHEMBL11131863 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Levothyroxine SCHEMBL3286699 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL61194 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Thyroxine SCHEMBL4575383 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Levothyroxine SCHEMBL4997979 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Thyroxine SCHEMBL7944262 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Levothyroxine SCHEMBL23098 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Thyroxine SCHEMBL11320096 | 0.99 | THRB (0.97) | THRBMEN1KMT2ATHRALMNA | |
| Thyroxine SCHEMBL2014581 | 0.99 | THRB (0.97) | THRBMEN1KMT2ATHRALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 55093 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747643-A1 | DEVICES AND METHODS FOR IMMUNOASSAY ANALYSIS OF BIOLOGICAL SAMPLES | Vital Biosciences Inc. (CA) | 2026-05-27 | — | — | EP | claimed |
| EP-4746923-A2 | DELIVERY SYSTEM COMPRISING LIPID OR POLYMERIC NANOPARTICLES COMPRISING THYROID HORMONES | FONDAZIONE RICCARDO TERZI E SILVIO ALBINI (IT) | 2026-05-27 | — | — | EP | claimed |
| EP-4747627-A1 | METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS | Matterworks Inc (US) | 2026-05-27 | — | — | EP | claimed |
| CN-122072264-A | Serum metabolite composition, kit and application | 中国科学院大连化学物理研究所 | 2026-05-22 | — | — | CN | claimed |
| CN-122031677-A | Leptin receptor agonist antibodies for the treatment of metabolic dysfunction or hypoleptinemia | 瑞泽恩制药公司 | 2026-05-15 | — | — | CN | claimed |
| WO-2025251988-A9 | REAGENT COMBINATION OR KIT FOR CONSTRUCTING EMBRYOID AND USE THEREOF | 广州国家实验室 | 2026-05-15 | — | — | WO | claimed |
| US-20260131121-A1 | MICRONEEDLE PATCH | DARWIN PRECISIONS CORP (TW) | 2026-05-14 | — | — | US | claimed |
| CN-115925637-B | Oxfendazole hapten and artificial antigen as well as preparation methods and application thereof | 北京维德维康生物技术有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-122028939-A | Thyroid hormone delivery system comprising lipid or polymer nanoparticles | 里卡尔多·泰尔齐与西尔维奥·阿尔比尼基金会 | 2026-05-12 | — | — | CN | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| US-4001583-A | COVALENTLY BOUND BIOLOGICAL SUBSTANCES TO PLASTIC MATERIALS AND USE IN RADIOASSAY | BARRETT M JAMES | 1977-01-04 | — | — | US | claimed |
| US-3995019-A | FOR RADIOIMMUNOASSAY CONSISTING OF A SPECIFIC ANTIBODY RADIOLABELED, ANTIGEN, POLYETHYLENE GLYCOL, AND GAMMA GLOBULIN | BAXTER TRAVENOL LABORATORIES, INC. (US) | 1976-11-30 | — | — | US | claimed |
| US-3983000-A | BONDED VIA AN O-DIANISIDINE RESIDUE | CORNING GLASS WORKS (US) | 1976-09-28 | — | — | US | claimed |
| US-3970746-A | RADIOACTIVITY | Premachandra, Bhartur (US) | 1976-07-20 | — | — | US | claimed |
| US-3962039-A | PEPSIN | CENTER FOR LABORATORY MEDICINE (US) | 1976-06-08 | — | — | US | claimed |
| US-3960492-A | Method for determining an index of binding protein content of blood | NUCLEAR DIAGNOSTICS, INC. (US) | 1976-06-01 | — | — | US | claimed |
| US-3947564-A | Radioactive determination of serum thyroxine | BIO-RAD LABORATORIES (US) | 1976-03-30 | — | — | US | claimed |
| US-3946109-A | THYROXINE, VITAMIN A, E, OR T | KOLB ERNST | 1976-03-23 | — | — | US | claimed |
| US-3941564-A | Method for assessing thyroid function | MILES LABORATORIES, INC. (US) | 1976-03-02 | — | — | US | claimed |
| US-3938953-A | Process and device for blood examination using substances labelled with radioactive nuclides | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-02-17 | — | — | US | claimed |