Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thyroxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 11/20 | 1.00 |
| ▸ | THRA known ✓ | P10827 | 7/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | PPARG | P37231 | 5/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | USP2 | O75604 | 3/20 | 1.00 |
| ▸ | TTR | P02766 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | RXRA | P19793 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dextrothyroxine SCHEMBL30885760 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Thyroxine SCHEMBL11131863 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Levothyroxine SCHEMBL3286699 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Dextrothyroxine SCHEMBL61194 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Thyroxine SCHEMBL26147 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Levothyroxine SCHEMBL4997979 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Thyroxine SCHEMBL7944262 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Levothyroxine SCHEMBL23098 | 1.00 | THRB (1.00) | THRBMEN1KMT2ATHRALMNA | |
| Thyroxine SCHEMBL11320096 | 0.99 | THRB (0.97) | THRBMEN1KMT2ATHRALMNA | |
| Thyroxine SCHEMBL2014581 | 0.99 | THRB (0.97) | THRBMEN1KMT2ATHRALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101023349-B | Biomarker for ovarian cancer | 约翰·霍普金斯大学 | 2016-11-02 | — | — | CN | claimed |
| CN-110338843-A | Tissue-estimating method, apparatus, equipment and computer readable storage medium | 无锡海斯凯尔医学技术有限公司 | 2019-10-18 | — | — | CN | disclosed |
| CN-107655878-B | For detecting the micro-fluidic chemiluminescence detection system of the magnetic particle of thyroid function | 北京华科泰生物技术股份有限公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-103889407-A | Novel therapies for transthyretin-associated amyloidosis | SOM INNOVATION BIOTECH S L | 2014-06-25 | — | — | CN | disclosed |
| CN-101897700-A | Compositions and method with non-naturally occurring prostaglandins treatment alopecia | PROCTER & GAMBLE | 2010-12-01 | — | — | CN | disclosed |
| CN-101229171-A | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins | UNIV DUKE (US) | 2008-07-30 | — | — | CN | disclosed |
| WO-2008088343-A1 | METHODS FOR INDIVIDUALIZED HEALTH ASSESSMENT SERVICE | BIOPHYSICAL CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |
| CN-100384425-C | Compositions and methods for treating hair loss using non-natural prostaglandins | PROCTER & GAMBLE (US) | 2008-04-30 | — | — | CN | disclosed |
| CN-1221238-C | Compositions and methods for treating hair loss using oximyl-and hydroxylamino-prostaglandins | PROCTER & GAMBLE (US) | 2005-10-05 | — | — | CN | disclosed |
| US-20050159352-A1 | Use of monocarboxylate transporter protein for thyroid hormone transport | STICHTING TOT BEVORDERING VAN DE WETENSCHAP DER ENDOCRINOLOGIE (NL) | 2005-07-21 | — | — | US | disclosed |
| WO-2003099864-A1 | USE OF MONOCARBOXYLATE TRANSPORTER PROTEIN FOR THYROID HORMONE TRANSPORT | STICHTING TOT BEVORDERING VAN DE WETENSCHAP DER ENDOCRINOLOGIE (NL) | 2003-12-04 | — | — | WO | disclosed |
| CN-1419437-A | Compositions and method for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins | PROCTER & GAMBLE (US) | 2003-05-21 | — | — | CN | disclosed |
| CN-1419439-A | Compositions and methods for treating hair loss using oximino-and hydroxylamino-prostaglandins | PROCTER & GAMBLE (US) | 2003-05-21 | — | — | CN | disclosed |
| CN-1419438-A | Compositions and methods for treating hair loss using 2-decarboxylated-2-phosphosubunit derivatives | PROCTER & GAMBLE (US) | 2003-05-21 | — | — | CN | disclosed |
| WO-1997017951-A1 | STABILIZED THYROID HORMONE PREPARATIONS AND METHODS OF MAKING SAME | KNOLL PHARMACEUTICAL COMPANY (US) | 1997-05-22 | — | — | WO | disclosed |
| WO-1993017335-A1 | BRIDGE IMMUNOASSAY | TRITON DIAGNOSTICS, INC. (US) | 1993-09-02 | — | — | WO | disclosed |
| US-4812396-A | REFRACTIVE PARTICLES WITH LIGAND COATING | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-03-14 | — | — | US | disclosed |
| US-4812395-A | REFRACTIVE PARTICLES WITH LIGAND COATING | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-03-14 | — | — | US | disclosed |
| US-4399121-A | Iodothyronine immunogens and antibodies | MILES LABORATORIES, INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4358604-A | ANTIBODIES-USEFUL IN IMMUNOASSAY | MILES LABORATORIES, INC. (US) | 1982-11-09 | — | — | US | disclosed |