SCHEMBL26150445 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	SLC6A4	P31645	2/20	0.40

▸	NOS2	P35228	2/20	0.40

▸	GABRA1	P14867	6/20	0.37

▸	GABRG2	P18507	6/20	0.37

▸	GABRB3	P28472	6/20	0.37

▸	GABRA3	P34903	6/20	0.37

▸	GABRA5	P31644	5/20	0.37

▸	CYP11B1	P15538	1/20	0.37

▸	CYP11B2	P19099	1/20	0.37

▸	AR	P10275	7/20	0.36

▸	GPR119	Q8TDV5	1/20	0.36

▸	TRPV4	Q9HBA0	1/20	0.34

▸	GABRA2	P47869	2/20	0.34

▸	SCN9A	Q15858	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19412370	0.82	SQOR (0.37)	CYP11B1CYP11B2ARTRPV4
SCHEMBL14658984	0.78	AR (0.41)	SLC6A4NOS2ARGPR119
SCHEMBL1460417	0.78	KDM4E (0.42)	SLC6A4NOS2ARTRPV4
SCHEMBL2130348	0.78	KHK (0.41)	SLC6A4NOS2ARGPR119
SCHEMBL14955073	0.78	TRPV4 (0.39)	SLC6A4NOS2GABRA1GABRG2GABRB3
SCHEMBL25415107	0.78	KHK (0.41)	SLC6A4NOS2ARGPR119
SCHEMBL12167442	0.78	SLC6A4 (0.42)	SLC6A4NOS2GABRA1GABRG2GABRB3
SCHEMBL31042250	0.78	KHK (0.41)	SLC6A4NOS2ARGPR119
SCHEMBL29480826	0.78	AR (0.41)	SLC6A4NOS2ARGPR119
SCHEMBL16805012	0.78	SLC6A4 (0.39)	SLC6A4NOS2GABRA1GABRG2GABRB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2023083210-A1	SUBSTITUTED NAPHTHYRIDINONE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF	上海海雁医药科技有限公司	2023-05-19	—	—	WO	disclosed