Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 10/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.51 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | SCN4A | P35499 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26162605 | 0.87 | MRGPRX4 (0.59) | MRGPRX4FFAR1FFAR4MAOAMAOB | |
| SCHEMBL26162600 | 0.82 | MRGPRX4 (0.60) | MRGPRX4FFAR1MAOAMAOBSMN1; SMN2 | |
| SCHEMBL26162607 | 0.78 | MRGPRX4 (0.57) | MRGPRX4MAOAMAOB | |
| SCHEMBL26162602 | 0.77 | MRGPRX4 (0.58) | MRGPRX4SMN1; SMN2 | |
| SCHEMBL13144443 | 0.77 | MRGPRX4 (0.68) | MRGPRX4FFAR1FFAR4SLC6A4SCN4A | |
| SCHEMBL22480853 | 0.75 | MRGPRX4 (1.00) | MRGPRX4SMN1; SMN2 | |
| SCHEMBL26162592 | 0.75 | L3MBTL1 (0.45) | MRGPRX4MAOAMAOBSMN1; SMN2 | |
| SCHEMBL22480859 | 0.74 | MRGPRX4 (0.64) | MRGPRX4FFAR1FFAR4ANO1SCN4A | |
| SCHEMBL22480934 | 0.74 | MRGPRX4 (0.64) | MRGPRX4FFAR1FFAR4ANO1SCN4A | |
| SCHEMBL20629081 | 0.74 | MRGPRX4 (0.58) | MRGPRX4FFAR1FFAR4SLC6A4SCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840521-B2 | Modulators of Mas-related G-protein receptor X4 and related products and methods | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-12-12 | — | — | US | disclosed |
| US-20230159474-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | INCYTE CORPORATION | 2023-05-25 | — | — | US | disclosed |
| US-11643399-B2 | Modulators of mas-related G-protein receptor X4 and related products and methods | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11840521-B2 | Modulators of Mas-related G-protein receptor X4 and related products and methods | MRGPRX4, MRGPRX1, MRGPRX2 | MRGPRX4 1/4885FFAR1 119/4885FFAR4 80/4885 |
| US-11643399-B2 | Modulators of mas-related G-protein receptor X4 and related products and methods | MRGPRX4, MRGPRX1, MRGPRX2 | MRGPRX4 1/4885FFAR1 119/4885FFAR4 80/4885 |
| US-20230159474-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | MRGPRX4, MRGPRX1, MRGPRX2 | MRGPRX4 1/4885FFAR1 119/4885FFAR4 80/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.