Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25753972 | 0.95 | GAA (0.37) | ALDH1A1SMN1; SMN2NR1H4MAPTGAA | |
| SCHEMBL22327196 | 0.92 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2HTTNR1H4MAPT | |
| SCHEMBL25753752 | 0.92 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2NR1H4MAPTGAA | |
| SCHEMBL26167941 | 0.91 | MAOB (0.41) | ALDH1A1SMN1; SMN2NR1H4KMT2AMEN1 | |
| SCHEMBL26167914 | 0.85 | HPGD (0.40) | ALDH1A1SMN1; SMN2HTTNR1H4MAPT | |
| SCHEMBL23106220 | 0.85 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2HTTMAPTGAA | |
| SCHEMBL26010471 | 0.85 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2HTTMAPTGAA | |
| SCHEMBL24002371 | 0.84 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2HTTMAPTGAA | |
| SCHEMBL26167749 | 0.84 | SMN1; SMN2 (0.36) | ALDH1A1SMN1; SMN2HTTNR1H4MAPT | |
| SCHEMBL26167742 | 0.83 | SMN1; SMN2 (0.36) | ALDH1A1SMN1; SMN2HTTNR1H4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230160001-A1 | NUCLEOTIDE CLEAVABLE LINKERS WITH RIGID SPACERS AND USES THEREOF | FIRST-CITIZENS BANK & TRUST COMPANY | 2023-05-25 | — | — | US | disclosed |