Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL261516 | 0.85 | AKR1B1 (0.50) | AKR1B1KDM4ELMNASMN1; SMN2AKR1C3 | |
| SCHEMBL29459928 | 0.85 | AKR1B1 (0.50) | AKR1B1KDM4ELMNASMN1; SMN2AKR1C3 | |
| SCHEMBL2239127 | 0.81 | AKR1B1 (0.57) | AKR1B1KDM4ELMNASMN1; SMN2THRB | |
| SCHEMBL18301609 | 0.81 | AKR1B1 (0.52) | AKR1B1KDM4ELMNASMN1; SMN2GPR17 | |
| SCHEMBL22031847 | 0.79 | AKR1B1 (0.48) | AKR1B1KDM4ELMNASMN1; SMN2PTGDR2 | |
| SCHEMBL29457633 | 0.79 | AKR1B1 (0.48) | AKR1B1KDM4ELMNASMN1; SMN2PTGDR2 | |
| SCHEMBL3730371 | 0.79 | P2RX7 (0.48) | AKR1B1KDM4ELMNASMN1; SMN2PTGDR2 | |
| SCHEMBL12245353 | 0.79 | AKR1B1 (0.44) | AKR1B1KDM4ESMN1; SMN2PTGDR2THRB | |
| SCHEMBL18585398 | 0.77 | TAAR1 (0.34) | KDM4E | |
| SCHEMBL3471284 | 0.76 | PPARA (0.35) | KDM4EFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101605785-B | Pyrido-pyrazine derivatives useful as herbicidal compounds | SYNGENTA LTD GB | 2013-04-10 | — | — | CN | disclosed |
| EP-2057154-B1 | PYRIDO [2, 3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LTD (GB) | 2012-11-14 | — | — | EP | disclosed |
| EP-2057154-B1 | PYRIDO [2, 3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LTD (GB) | 2012-11-14 | — | — | EP | disclosed |
| US-8217055-B2 | Pyrido-pyrazine derivatives useful as herbicidal compounds | SYNGENTA CROP PROTECTION LLC (US) | 2012-07-10 | — | — | US | disclosed |
| US-8217055-B2 | Pyrido-pyrazine derivatives useful as herbicidal compounds | SYNGENTA CROP PROTECTION LLC (US) | 2012-07-10 | — | — | US | disclosed |
| US-8217055-B2 | Pyrido-pyrazine derivatives useful as herbicidal compounds | SYNGENTA CROP PROTECTION LLC (US) | 2012-07-10 | — | — | US | disclosed |
| CN-101490051-B | Pyrido [2, 3-b] pyrazine derivatives useful as herbicidal compounds | SYNGENTA LTD | 2012-05-23 | — | — | CN | disclosed |
| US-8133847-B2 | Pyrido[2,3-B]pyrazine derivatives useful as herbicidal compounds | SYNGENTA LIMITED (GB) | 2012-03-13 | — | — | US | disclosed |
| US-8133847-B2 | Pyrido[2,3-B]pyrazine derivatives useful as herbicidal compounds | SYNGENTA LIMITED (GB) | 2012-03-13 | — | — | US | disclosed |
| US-8133847-B2 | Pyrido[2,3-B]pyrazine derivatives useful as herbicidal compounds | SYNGENTA LIMITED (GB) | 2012-03-13 | — | — | US | disclosed |
| US-20090305892-A1 | PYRIDO[2,3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2009-12-10 | — | — | US | disclosed |
| US-20090305892-A1 | PYRIDO[2,3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2009-12-10 | — | — | US | disclosed |
| US-20090305892-A1 | PYRIDO[2,3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2009-12-10 | — | — | US | disclosed |
| EP-2102205-A1 | PYRIDO-PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | Syngenta Limited (GB) | 2009-09-23 | — | — | EP | disclosed |
| CN-101490051-A | Pyrido [2, 3-b] pyrazine derivatives useful as herbicidal compounds | SYNGENTA LTD (GB) | 2009-07-22 | — | — | CN | disclosed |
| EP-2057154-A1 | PYRIDO [2, 3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | Syngenta Limited (GB) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008071918-A1 | PYRIDO-PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2008-06-19 | — | — | WO | disclosed |
| WO-2008071918-A1 | PYRIDO-PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2008-06-19 | — | — | WO | disclosed |
| WO-2008009908-A1 | PYRIDO [2, 3-B] PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008009908-A1 | PYRIDO [2, 3-B] PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090305892-A1 | PYRIDO[2,3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | PNPO, CBR3, CBR1 | AKR1B1 75/4885KDM4E 2152/4885LMNA 3694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.