Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.56 |
| ▸ | MTOR | P42345 | 4/20 | 0.56 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 6/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 2/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15756786 | 0.84 | FLT3 (0.59) | PIK3CAMTORMAP3K14FLT3DYRK1A | |
| SCHEMBL15288131 | 0.78 | FYN (0.55) | PIK3CAMTORMAP3K14FLT3PRMT5 | |
| SCHEMBL26178953 | 0.78 | KDR (0.53) | PIK3CAMTORMAP3K14FLT3KDR | |
| SCHEMBL15757685 | 0.77 | DYRK1A (0.52) | PIK3CAMTORMAP3K14FLT3DYRK1A | |
| SCHEMBL15756965 | 0.77 | MAP3K14 (0.54) | PIK3CAMTORMAP3K14FLT3DYRK1A | |
| SCHEMBL22851709 | 0.76 | FLT3 (0.71) | PIK3CAMTORFLT3DYRK1AKDR | |
| SCHEMBL4254179 | 0.76 | MAP3K14 (0.56) | PIK3CAMTORMAP3K14FLT3KDR | |
| SCHEMBL15756997 | 0.75 | PIK3CA (0.55) | PIK3CAMTORMAP3K14FLT3MAPK14 | |
| SCHEMBL18041661 | 0.74 | PIK3CA (0.47) | PIK3CAMTORMAP3K14FLT3AHR | |
| SCHEMBL19586821 | 0.74 | PIK3CA (0.65) | PIK3CAMTORMAP3K14FLT3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230190717-A1 | P38 GAMMA INHIBITORS AND METHOD OF USE THEREOF | CITY OF HOPE | 2023-06-22 | — | — | US | disclosed |
| US-20230190717-A1 | P38 GAMMA INHIBITORS AND METHOD OF USE THEREOF | CITY OF HOPE | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230190717-A1 | P38 GAMMA INHIBITORS AND METHOD OF USE THEREOF | CDC42BPG, MAPK1, MAPK7 | PIK3CA 261/4885MTOR 752/4885MAP3K14 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.