Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2624405 | 0.91 | CYP2E1 (0.40) | CYP2E1NR1I2 | |
| SCHEMBL2620492 | 0.91 | CYP2E1 (0.40) | CYP2E1NR1I2 | |
| SCHEMBL2620425 | 0.90 | CYP2E1 (0.39) | CYP2E1NR1I2S1PR1 | |
| SCHEMBL10247002 | 0.88 | CYP2E1 (0.38) | CYP2E1NR1I2 | |
| SCHEMBL2620437 | 0.86 | OPRM1 (0.30) | — | |
| SCHEMBL2624383 | 0.86 | OPRM1 (0.30) | — | |
| SCHEMBL10249894 | 0.85 | CYP2E1 (0.36) | CYP2E1NR1I2HTT | |
| SCHEMBL2620434 | 0.85 | CYP2E1 (0.42) | CYP2E1NR1I2HTT | |
| SCHEMBL2620436 | 0.85 | CYP2E1 (0.35) | CYP2E1NR1I2 | |
| SCHEMBL12447295 | 0.83 | CYP2E1 (0.47) | CYP2E1NR1I2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120164103-A1 | Compounds and Methods for the Treatment or Prevention of Flavivirus Infections | VERTEX PHARMACEUTICALS (CANADA) INCORPORATED (CA) | 2012-06-28 | — | — | US | disclosed |
| US-8158675-B2 | Compounds and methods for the treatment or prevention of Flavivirus infections | VERTEX PHARMACEUTICALS (CANADA) INCORPORATED (CA) | 2012-04-17 | — | — | US | disclosed |
| US-20100093775-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VIROCHEM PHARMA INC. (CA) | 2010-04-15 | — | — | US | disclosed |
| US-7569600-B2 | Compounds and methods for the treatment of prevention of Flavivirus infections | VIROCHEM PHARMA INC. (CA) | 2009-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120164103-A1 | Compounds and Methods for the Treatment or Prevention of Flavivirus Infections | ZC3HAV1, YBX1, HAX1 | CYP2E1 47/4885NR1I2 441/4885S1PR1 320/4885 |
| US-20100093775-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | ZC3HAV1, YBX1, HAX1 | CYP2E1 47/4885NR1I2 441/4885S1PR1 320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.