Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26199046 | 1.00 | CYP2D6 (0.36) | CYP2D6CYP2C19ALDH1A1POLBHDAC6 | |
| SCHEMBL10018013 | 1.00 | CYP2D6 (0.36) | CYP2D6CYP2C19ALDH1A1POLBHDAC6 | |
| SCHEMBL11521154 | 0.84 | CYP2D6 (0.34) | CYP2D6CYP2C19ALDH1A1ANPEPDNPEP | |
| SCHEMBL8932181 | 0.83 | CYP2D6 (0.54) | CYP2D6CYP2C19ALDH1A1POLBHDAC6 | |
| SCHEMBL25592253 | 0.82 | ACACB (0.31) | ALDH1A1 | |
| SCHEMBL24771260 | 0.82 | CYP2C19 (0.33) | CYP2D6CYP2C19ALDH1A1POLBHDAC6 | |
| SCHEMBL9497738 | 0.82 | ANPEP (0.34) | CYP2D6CYP2C19ALDH1A1ANPEPDNPEP | |
| SCHEMBL24478556 | 0.81 | POLB (0.39) | CYP2D6CYP2C19ALDH1A1POLBHDAC6 | |
| SCHEMBL12160518 | 0.80 | RIPK1 (0.44) | CYP2D6CYP2C19ALDH1A1POLB | |
| SCHEMBL23872347 | 0.79 | CYP2C19 (0.34) | CYP2D6CYP2C19ALDH1A1POLBHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-09-07 | — | — | US | disclosed |
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | YAP1, TERF2IP, TEAD1 | CYP2D6 4510/4885CYP2C19 4791/4885ALDH1A1 3813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.