Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16077020 | 0.98 | TDP1 (0.46) | TDP1LMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL17908742 | 0.89 | LMNA (0.50) | TDP1LMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL17908770 | 0.89 | LMNA (0.50) | TDP1LMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL17908841 | 0.89 | LMNA (0.50) | TDP1LMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL25868407 | 0.85 | TDP1 (0.57) | TDP1LMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL26199739 | 0.82 | LMNA (0.50) | LMNAALDH1A1HSD17B10HTTTSHR | |
| SCHEMBL26199851 | 0.82 | LMNA (0.46) | LMNAALDH1A1HSD17B10HTTTSHR | |
| SCHEMBL16467061 | 0.80 | TDP1 (0.47) | TDP1ALDH1A1HSD17B10KDM4ECA1 | |
| SCHEMBL10404989 | 0.80 | LMNA (0.57) | TDP1LMNAALDH1A1HSD17B10HTT | |
| SCHEMBL131802 | 0.79 | LMNA (0.54) | TDP1LMNAALDH1A1HTTCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3621624-B1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME LLC (US) | 2023-08-30 | — | — | EP | disclosed |