Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | TOP2A | P11388 | 3/20 | 0.52 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9146620 | 0.95 | KDM4E (0.59) | KDM4EALDH1A1LMNATOP2ATOP2B | |
| SCHEMBL27977216 | 0.86 | KDM4E (0.68) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7127052 | 0.85 | KDM4E (0.67) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1243805 | 0.84 | KDM4E (0.63) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL2744582 | 0.84 | KDM4E (0.59) | KDM4EALDH1A1LMNATOP2ATOP2B | |
| SCHEMBL29766836 | 0.84 | KDM4E (0.59) | KDM4EALDH1A1LMNATOP2ATOP2B | |
| SCHEMBL7121601 | 0.84 | KDM4E (0.69) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL10757644 | 0.84 | KDM4E (0.47) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL28458144 | 0.83 | KDM4E (0.57) | KDM4EALDH1A1LMNATOP2ATOP2B | |
| Hydrochloric Acid SCHEMBL6004997 | 0.83 | KDM4E (0.57) | KDM4EALDH1A1LMNATOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103965163-B | A kind of carbostyril derivative containing pyrimidine ring and its production and use | FUDAN UNIVERSITY (CN) | 2016-01-20 | — | — | CN | disclosed |
| CN-103965163-A | Pyrimidine ring-containing quinolone derivatives as well as preparation method and application thereof | UNIV FUDAN | 2014-08-06 | — | — | CN | disclosed |
| US-8629126-B2 | Quinolone derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC. (JP) | 2014-01-14 | — | — | US | disclosed |
| US-20120136025-A1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2012-05-31 | — | — | US | disclosed |
| US-8133882-B2 | Quinolone derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC (JP) | 2012-03-13 | — | — | US | disclosed |
| US-20090197834-A1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2009-08-06 | — | — | US | disclosed |
| CN-101400655-A | Quinolone derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC (JP) | 2009-04-01 | — | — | CN | disclosed |
| EP-1995240-A1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Astellas Pharma Inc. (JP) | 2008-11-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136025-A1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | P2RY10, P2RY12, P2RY11 | KDM4E 3062/4885MEN1 3327/4885KMT2A 2966/4885 |
| US-20090197834-A1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | P2RY12, P2RY11, P2RY10 | KDM4E 3128/4885MEN1 2994/4885KMT2A 2967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.