Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TOP2A | P11388 | 3/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29576694 | 0.94 | KDM4E (0.59) | KDM4EMEN1KMT2APIK3CDPIK3R1 | |
| SCHEMBL7578838 | 0.94 | KDM4E (0.59) | KDM4EMEN1KMT2APIK3CDPIK3R1 | |
| SCHEMBL27977216 | 0.85 | KDM4E (0.68) | KDM4EMEN1KMT2APIK3CDPIK3R1 | |
| SCHEMBL262202 | 0.84 | KDM4E (0.67) | KDM4EMEN1KMT2APIK3CDPIK3R1 | |
| SCHEMBL7127052 | 0.84 | KDM4E (0.67) | KDM4EMEN1KMT2APIK3CDPIK3R1 | |
| SCHEMBL7131487 | 0.83 | LMNA (0.55) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL23497751 | 0.82 | LMNA (0.54) | KDM4EPIK3CDPIK3R1PIK3CAPIK3CG | |
| SCHEMBL7127495 | 0.82 | KDM4E (0.65) | KDM4EMEN1KMT2APIK3CDPIK3R1 | |
| SCHEMBL2679599 | 0.82 | KDM4E (1.00) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL27977084 | 0.81 | KDM4E (0.60) | KDM4EMEN1KMT2APIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1136198-C | Novel benzyl pyrimidines | ��������ҩ�ɷ�����˾ | 2004-01-28 | — | — | CN | disclosed |
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | disclosed |
| US-5763450-A | BACTERICIDES; TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| CN-1166831-A | Novel benzyl pyrimidines | HOFFMANN LA ROCHE (CH) | 1997-12-03 | — | — | CN | disclosed |
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016046-A2 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-30 | — | — | WO | disclosed |