Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | NQO2 | P16083 | 2/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 9/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 7/20 | 0.36 |
| ▸ | TUBB | P07437 | 7/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 7/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 7/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 7/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 7/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 7/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 7/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 7/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 7/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 7/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 7/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13917719 | 0.88 | AKR1B1 (0.40) | AKR1B1TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL355474 | 0.84 | AKR1B1 (0.50) | AKR1B1ACHECYP19A1NQO2TUBB1 | |
| SCHEMBL2757192 | 0.79 | AKR1B1 (0.46) | AKR1B1ACHECYP19A1NQO2TUBB1 | |
| SCHEMBL2622282 | 0.75 | PDE3B (0.43) | AKR1B1ACHECYP19A1NQO2TUBB1 | |
| SCHEMBL353813 | 0.72 | AKR1B1 (0.51) | AKR1B1ACHECYP19A1NQO2TUBB1 | |
| SCHEMBL353909 | 0.70 | MEN1 (0.43) | AKR1B1CYP19A1NQO2CYP3A4MAPT | |
| SCHEMBL12664485 | 0.70 | AKR1B1 (0.43) | AKR1B1CYP19A1NQO2CYP3A4MAPT | |
| SCHEMBL12664482 | 0.69 | RAD52 (0.42) | ACHECYP19A1NQO2TUBB1TUBB4A | |
| SCHEMBL353866 | 0.69 | AKR1B1 (0.40) | AKR1B1ACHECYP19A1NQO2 | |
| SCHEMBL4305857 | 0.68 | ACHE (0.54) | ACHECYP19A1NQO2TUBB1TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163805-B2 | Small molecule antagonists of Bcl-2 family proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163805-B2 | Small molecule antagonists of Bcl-2 family proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-04-24 | — | — | US | disclosed |
| US-20100069344-A1 | SMALL MOLECULE ANTAGONISTS OF BCL2 FAMILY PROTEINS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-03-18 | — | — | US | disclosed |
| US-20100069344-A1 | SMALL MOLECULE ANTAGONISTS OF BCL2 FAMILY PROTEINS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-03-18 | — | — | US | disclosed |
| US-20090092684-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | GEORGETOWN UNIVERSITY | 2009-04-09 | — | — | US | disclosed |
| US-20090092684-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | GEORGETOWN UNIVERSITY | 2009-04-09 | — | — | US | disclosed |
| US-20090082424-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | REGENTS OF THE UNIVERSITY OF MICHIGAN, THE | 2009-03-26 | — | — | US | disclosed |
| US-7432304-B2 | Small molecule antagonists of Bcl-2 family proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432304-B2 | Small molecule antagonists of Bcl-2 family proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090092684-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | BCL2, BCL2L1, BCL2L2 | AKR1B1 1880/4885ACHE 4874/4885CYP19A1 3676/4885 |
| US-20100069344-A1 | SMALL MOLECULE ANTAGONISTS OF BCL2 FAMILY PROTEINS | BCL2L1, BCL2, BCL2L11 | AKR1B1 1397/4885ACHE 4878/4885CYP19A1 3396/4885 |
| US-20090082424-A1 | SMALL MOLECULE ANTAGONISTS OF BCL-2 FAMILY PROTEINS | BCL2, BCL2L1, BCL2L2 | AKR1B1 1880/4885ACHE 4874/4885CYP19A1 3676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.