Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 6/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.40 |
| ▸ | PDE5A | O76074 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL354548 | 0.96 | RAD52 (0.44) | RAD52PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL7200688 | 0.77 | TUBB1 (0.45) | RAD52PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL811100 | 0.75 | ALDH1A1 (0.52) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7129430 | 0.74 | TUBB1 (0.50) | PDE1APDE1BPDE3BPDE1CPDE3A | |
| SCHEMBL811025 | 0.73 | ALDH1A1 (0.50) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8037059 | 0.71 | AKR1B1 (0.42) | PDE3BPDE3AMAPTTUBB4ATUBB | |
| SCHEMBL353813 | 0.70 | AKR1B1 (0.51) | PDE3BPDE3AMAPTTUBB4ATUBB | |
| SCHEMBL2622282 | 0.70 | PDE3B (0.43) | PDE1APDE1BPDE3BPDE1CPDE3A | |
| SCHEMBL355474 | 0.69 | AKR1B1 (0.50) | KDM4EMAPTTUBB4ATUBBTUBA3C | |
| SCHEMBL2622281 | 0.69 | AKR1B1 (0.38) | MAPTTUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937193-B2 | Apogossypolone derivatives as anticancer agents | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-01-20 | — | — | US | disclosed |
| US-20110112112-A1 | APOGOSSYPOLONE DERIVATIVES AS ANTICANCER AGENTS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112112-A1 | APOGOSSYPOLONE DERIVATIVES AS ANTICANCER AGENTS | CYP17A1, HSD17B7, CYP27A1 | RAD52 2597/4885PDE1A 4748/4885PDE1B 4659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.