Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | PRKX | P51817 | 1/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.49 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.49 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26236387 | 0.91 | NAMPT (0.49) | NAMPTMAPK1ALDH1A1HPGD | |
| SCHEMBL26236379 | 0.90 | NAMPT (0.58) | NAMPTMAPK1ROCK2RPS6KA5MAP4K4 | |
| SCHEMBL26236398 | 0.81 | NAMPT (0.50) | NAMPTMAPK1ROCK2RPS6KA5MAP4K4 | |
| SCHEMBL26236408 | 0.78 | NAMPT (0.48) | NAMPTMAPK1ALDH1A1HPGD | |
| SCHEMBL26233776 | 0.78 | MAPK1 (0.62) | NAMPTMAPK1ROCK2RPS6KA5MAP4K4 | |
| SCHEMBL26236473 | 0.75 | NAMPT (0.47) | NAMPTMAPK1ROCK2ROCK1POLB | |
| SCHEMBL16047461 | 0.74 | ALDH1A1 (0.48) | NAMPTMAPK1ROCK2RPS6KA5MAP4K4 | |
| SCHEMBL26236464 | 0.74 | NAMPT (0.49) | NAMPTMAPK1ROCK2RPS6KA5MAP4K4 | |
| SCHEMBL26236479 | 0.73 | NAMPT (0.46) | NAMPTMAPK1HPGD | |
| SCHEMBL6028765 | 0.72 | MAPK14 (0.55) | NAMPTMAPK1ROCK2RPS6KA5MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230286978-A1 | INDAZOLE DERIVATIVES AS INHIBITORS OF SARM1 | DISARM THERAPEUTICS, INC. | 2023-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230286978-A1 | INDAZOLE DERIVATIVES AS INHIBITORS OF SARM1 | SARM1, SMN1; SMN2, AIFM1 | NAMPT 2263/4885MAPK1 1367/4885ROCK2 2889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.