Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.71 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.56 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.56 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26239199 | 0.85 | KCNH2 (0.80) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL22831328 | 0.75 | KCNH2 (0.79) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| Dofetilide SCHEMBL6102734 | 0.72 | KCNH2 (1.00) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| Dofetilide SCHEMBL16135 | 0.72 | KCNH2 (1.00) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL24600588 | 0.71 | KCNH2 (0.73) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL7024969 | 0.71 | KCNH2 (0.73) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| Dofetilide SCHEMBL8362214 | 0.71 | KCNH2 (0.97) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL20231006 | 0.69 | KCNH2 (0.70) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL3929250 | 0.69 | KCNH2 (1.00) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL11681780 | 0.68 | TSHR (0.50) | KCNH2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11731938-B2 | Ultra short acting anti-arrhythmic agents | ACADEMIC PHARMACEUTICALS INC (US) | 2023-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11731938-B2 | Ultra short acting anti-arrhythmic agents | CACNA1G, SCN5A, CACNA1F | KCNH2 51/4885CACNA1F 3/4885CHRM2 1597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.