Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.73 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.62 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.59 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.59 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790478 | 0.94 | KCNH2 (0.76) | KCNH2HRH3CACNA1FCHRM2ACHE | |
| SCHEMBL2022333 | 0.89 | KCNH2 (0.56) | KCNH2HRH3CACNA1FCHRM2ACHE | |
| SCHEMBL9628264 | 0.88 | KCNH2 (0.58) | KCNH2HRH3CACNA1FCHRM2ACHE | |
| Hydrochloric Acid SCHEMBL5159771 | 0.88 | KCNH2 (0.54) | KCNH2HRH3CACNA1FCHRM2ACHE | |
| SCHEMBL8789232 | 0.86 | KCNH2 (0.66) | KCNH2HRH3CACNA1FCHRM2ACHE | |
| SCHEMBL6575217 | 0.85 | CYP1A2 (0.67) | KCNH2AOC3 | |
| SCHEMBL9628293 | 0.84 | KCNH2 (0.88) | KCNH2HRH3CACNA1FCHRM2ACHE | |
| SCHEMBL9629107 | 0.84 | KCNH2 (0.54) | KCNH2HRH3CACNA1FCHRM2ACHE | |
| SCHEMBL9628071 | 0.84 | KCNH2 (0.88) | KCNH2HRH3CACNA1FCHRM2ACHE | |
| Hydrochloric Acid SCHEMBL9054039 | 0.84 | BLM (0.68) | KCNH2AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115055066-B | Microporous polymer particle/polymer mixed matrix membrane and preparation method and application thereof | 南京工业大学 | 2023-07-07 | — | — | CN | claimed |
| CN-115055066-A | Microporous polymer particle/polymer mixed matrix membrane and preparation method and application thereof | 南京工业大学 | 2022-09-16 | — | — | CN | claimed |
| EP-3323500-B1 | MANUFACTURING METHOD FOR TRIPTYCENE POLYMER CARRIER FILM | NANJING UNIVERSITY OF TECHNOLOGY (CN) | 2021-01-27 | — | — | EP | claimed |
| US-10799836-B2 | Preparation method for triptyl polymer separation membrane | NANJING TECH UNIVERSITY (CN) | 2020-10-13 | — | — | US | claimed |
| US-10450267-B2 | Method for preparing N-[4-(2-{[2-(4-methane sulfonamidophenoxy) ethyl] (methyl)amino}ethyl)phenyl]methanesulfonamide (dofetilide) | FARMAK, A.S. (CZ) | 2019-10-22 | — | — | US | claimed |
| US-20190169121-A1 | METHOD FOR PREPARING N-[4-(2-{[2-(4-METHANE SULFONAMIDOPHENOXY) ETHYL](METHYL)AMINO}ETHYL)PHENYL]METHANESULFONAMIDE (DOFETILIDE) | FARMAK, A.S. (CZ) | 2019-06-06 | — | — | US | claimed |
| US-20180236408-A1 | A PREPARATION METHOD FOR TRIPTYL POLYMER SEPARATION MEMBRANE | NANJING TECH UNIVERSITY (CN) | 2018-08-23 | — | — | US | claimed |
| EP-3323500-A1 | MANUFACTURING METHOD FOR TRIPTYCENE POLYMER CARRIER FILM | Nanjing Tech University (CN) | 2018-05-23 | — | — | EP | claimed |
| EP-0245997-B1 | N-SUBSTITUTED P-AMINOETHYLSULPHON ANILIDES AS ANTIARRHYTHMIC AGENTS, AND INTERMEDIATES THEREFOR | Pfizer Limited (GB) | 1992-04-15 | — | — | EP | claimed |
| EP-0245997-A2 | N-substituted p-aminoethylsulphon anilides as antiarrhythmic agents, and intermediates therefor | Pfizer Limited (GB) | 1987-11-19 | — | — | EP | claimed |
| CN-115055066-B | Microporous polymer particle/polymer mixed matrix membrane and preparation method and application thereof | 南京工业大学 | 2023-07-07 | — | — | CN | disclosed |
| CN-115055066-A | Microporous polymer particle/polymer mixed matrix membrane and preparation method and application thereof | 南京工业大学 | 2022-09-16 | — | — | CN | disclosed |
| CN-108164429-B | Preparation method of dofetilide intermediate | 四川科瑞德凯华制药有限公司 | 2021-07-23 | — | — | CN | disclosed |
| EP-3323500-B1 | MANUFACTURING METHOD FOR TRIPTYCENE POLYMER CARRIER FILM | NANJING UNIVERSITY OF TECHNOLOGY (CN) | 2021-01-27 | — | — | EP | disclosed |
| US-10799836-B2 | Preparation method for triptyl polymer separation membrane | NANJING TECH UNIVERSITY (CN) | 2020-10-13 | — | — | US | disclosed |
| EP-0898964-A1 | Method for treating heart failure | PFIZER INC. (US) | 1999-03-03 | — | — | EP | disclosed |
| EP-0245997-B1 | N-SUBSTITUTED P-AMINOETHYLSULPHON ANILIDES AS ANTIARRHYTHMIC AGENTS, AND INTERMEDIATES THEREFOR | Pfizer Limited (GB) | 1992-04-15 | — | — | EP | disclosed |
| US-5079248-A | Antifibrillatory agents; side effect reduction | PFIZER INC. (US) | 1992-01-07 | — | — | US | disclosed |
| US-4959366-A | Anti-arrhythmic agents | PFIZER INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0245997-A2 | N-substituted p-aminoethylsulphon anilides as antiarrhythmic agents, and intermediates therefor | Pfizer Limited (GB) | 1987-11-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169121-A1 | METHOD FOR PREPARING N-[4-(2-{[2-(4-METHANE SULFONAMIDOPHENOXY) ETHYL](METHYL)AMINO}ETHYL)PHENYL]METHANESULFONAMIDE (DOFETILIDE) | SCN4A, HCN4, METTL14 | KCNH2 16/4885HRH3 2831/4885CACNA1F 20/4885 |
| US-10450267-B2 | Method for preparing N-[4-(2-{[2-(4-methane sulfonamidophenoxy) ethyl] (methyl)amino}ethyl)phenyl]methanesulfonamide (dofetilide) | SCN4A, HCN4, METTL14 | KCNH2 16/4885HRH3 2831/4885CACNA1F 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.