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SCHEMBL26241389

SCHEMBL26241389

Cc1cc(CC(=O)N2CCN(C)CC2C)on1

nearest known ligand 0.53

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ VHL P40337 6/20 0.53
▸ P2RX7 Q99572 1/20 0.42
▸ CCNE1 P24864 10/20 0.41
▸ CDK2 P24941 10/20 0.41
▸ GSK3B P49841 7/20 0.41
▸ ELOC Q15369 3/20 0.40
▸ ELOB Q15370 3/20 0.40
▸ NPC1 O15118 2/20 0.39
▸ RAB9A P51151 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20012510 0.85 VHL (0.51) VHLP2RX7CCNE1CDK2GSK3B
SCHEMBL20008980 0.84 VHL (0.50) VHLP2RX7CCNE1CDK2GSK3B
SCHEMBL21696556 0.82 CCNE1 (0.54) VHLCCNE1CDK2GSK3B
SCHEMBL21696439 0.82 CCNE1 (0.54) VHLCCNE1CDK2GSK3B
SCHEMBL21696706 0.80 CCNE1 (0.54) VHLCCNE1CDK2GSK3BNPC1
SCHEMBL15112607 0.74 VHL (0.55) VHLP2RX7CCNE1CDK2GSK3B
SCHEMBL32661830 0.73 VHL (0.51) VHLP2RX7CCNE1CDK2GSK3B
SCHEMBL21696674 0.72 VHL (0.50) VHLP2RX7CCNE1CDK2GSK3B
SCHEMBL15126220 0.72 VHL (0.53) VHLP2RX7CCNE1CDK2GSK3B
SCHEMBL26243988 0.72 P2RX7 (0.41) VHLP2RX7CCNE1CDK2GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3262036-B1 THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF GENENTECH INC (US) 2023-09-13 — — EP disclosed
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