Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 5/20 | 0.54 |
| ▸ | CDK2 | P24941 | 5/20 | 0.54 |
| ▸ | GSK3B | P49841 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | VHL | P40337 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21696439 | 0.95 | CCNE1 (0.54) | CCNE1CDK2GSK3BHPGDVHL | |
| SCHEMBL21696556 | 0.95 | CCNE1 (0.54) | CCNE1CDK2GSK3BHPGDVHL | |
| SCHEMBL15112607 | 0.82 | VHL (0.55) | CCNE1CDK2GSK3BVHLKMT2A | |
| SCHEMBL21696674 | 0.80 | VHL (0.50) | CCNE1CDK2GSK3BVHLKMT2A | |
| SCHEMBL26241389 | 0.80 | VHL (0.53) | CCNE1CDK2GSK3BVHLRAB9A | |
| SCHEMBL15126220 | 0.80 | VHL (0.53) | CCNE1CDK2GSK3BHPGDVHL | |
| SCHEMBL21697138 | 0.80 | CCNE1 (0.47) | CCNE1CDK2GSK3BVHL | |
| SCHEMBL13570435 | 0.79 | VHL (0.52) | CCNE1CDK2GSK3BVHL | |
| SCHEMBL21696738 | 0.79 | VHL (0.52) | CCNE1CDK2GSK3BVHL | |
| SCHEMBL20012510 | 0.78 | VHL (0.51) | CCNE1CDK2GSK3BVHL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608317-A1 | COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE | Yale University (US) | 2020-02-12 | — | — | EP | disclosed |