Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2632770 | 0.81 | TSHR (0.32) | — | |
| SCHEMBL6648783 | 0.78 | APLNR (0.34) | APLNR | |
| SCHEMBL8163993 | 0.77 | APLNR (0.38) | APLNRNR3C1 | |
| SCHEMBL14997543 | 0.77 | PTGS1 (0.35) | PTGS1PTGS2POLB | |
| SCHEMBL14998951 | 0.77 | PTGS1 (0.35) | PTGS1PTGS2APLNRPOLB | |
| SCHEMBL10996190 | 0.75 | TKT (0.35) | APLNRPOLB | |
| SCHEMBL15431031 | 0.72 | PIK3CA (0.33) | PTGS1PTGS2 | |
| SCHEMBL10691443 | 0.72 | P2RX3 (0.36) | POLB | |
| SCHEMBL21101088 | 0.72 | POLB (0.34) | PTGS1PTGS2POLB | |
| SCHEMBL19523168 | 0.72 | PTGS1 (0.33) | PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163763-B2 | Pyrimidine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163763-B2 | Pyrimidine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-04-24 | — | — | US | disclosed |