Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.44 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.44 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 4/20 | 0.33 |
| ▸ | CTSK | P43235 | 4/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 2/20 | 0.31 |
| ▸ | CTSB | P07858 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL262562 | 1.00 | CACNA2D1 (0.44) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL16694 | 0.98 | CACNA2D1 (0.45) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL2637586 | 0.98 | CACNA2D1 (0.45) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL16576 | 0.98 | CACNA2D1 (0.45) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Ammonia Solution, Strong SCHEMBL3024177 | 0.96 | CACNA2D1 (0.44) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Ammonia Solution, Strong SCHEMBL3024172 | 0.96 | CACNA2D1 (0.44) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Tert-Butylamine SCHEMBL4158435 | 0.89 | CACNA2D1 (0.43) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Tert-Butylamine SCHEMBL4158429 | 0.89 | CACNA2D1 (0.43) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL4390679 | 0.88 | CACNA2D1 (0.41) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL4387072 | 0.88 | CACNA2D1 (0.41) | CACNA2D1CACNB3CACNA1CPGRADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112941122-A | Preparation method of (S) -3-cyano-5-methylhexanoic acid | 浙江工业大学 | 2021-06-11 | — | — | CN | disclosed |
| US-8134023-B2 | Preparation of pregabalin and related compounds | PFIZER INC (US) | 2012-03-13 | — | — | US | disclosed |
| US-20120015412-A1 | Preparation of Pregabalin and Related Compounds | PFIZER INC | 2012-01-19 | — | — | US | disclosed |
| US-8044227-B2 | Preparation of pregabalin and related compounds | PFIZER INC. (US) | 2011-10-25 | — | — | US | disclosed |
| US-20110065168-A1 | Preparation of Pregabalin and Related Compounds | PFIZER INC | 2011-03-17 | — | — | US | disclosed |
| US-7838686-B2 | Preparation of pregabalin and related compounds | PFIZER INC. (US) | 2010-11-23 | — | — | US | disclosed |
| EP-1831154-B1 | PREPARATION OF PREGABALIN AND RELATED COMPOUNDS | WARNER LAMBERT CO (US) | 2010-01-13 | — | — | EP | disclosed |
| US-20090042262-A1 | Preparation of Pregabalin and Related Compounds | PFIZER INC | 2009-02-12 | — | — | US | disclosed |
| EP-1912931-A2 | PREPARATION OF (S)-PREGABALIN-NITRILE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-04-23 | — | — | EP | disclosed |
| US-20080015385-A1 | Preparation of (S)-pregabalin-nitrile | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-01-17 | — | — | US | disclosed |
| WO-2007143152-A2 | PREPARATION OF (S)-PREGABALIN-NITRILE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-12-13 | — | — | WO | disclosed |
| US-20050283023-A1 | Preparation of pregabalin and related compounds | HU SHANGHUI | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042262-A1 | Preparation of Pregabalin and Related Compounds | GABRE, GABRG1, GABRA6 | CACNA2D1 148/4885CACNB3 118/4885CACNA1C 104/4885 |
| US-20080015385-A1 | Preparation of (S)-pregabalin-nitrile | GABRE, GAP43, RIMKLA | CACNA2D1 635/4885CACNB3 127/4885CACNA1C 89/4885 |
| US-20050283023-A1 | Preparation of pregabalin and related compounds | GABRE, GABRG1, GABRA6 | CACNA2D1 148/4885CACNB3 118/4885CACNA1C 104/4885 |
| US-20110065168-A1 | Preparation of Pregabalin and Related Compounds | GABRE, GABRG1, GABRA6 | CACNA2D1 148/4885CACNB3 118/4885CACNA1C 104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.