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GABRG1

Gamma-aminobutyric acid receptor subunit gamm · Q8N1C3 · GABRG1 on Sugi Atlas →

109,802 patent compounds predicted against GABRG1, 57,383 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL15406 SCHEMBL15406 0.61 20/20
Fipronil Fipronil (SCHEMBL15088) 0.59 20/20
SCHEMBL41972 SCHEMBL41972 0.59 20/20
Fipronil Fipronil (SCHEMBL44222) 0.59 20/20
Ethiprole Ethiprole (SCHEMBL27048) 0.56 20/20
SCHEMBL25897 SCHEMBL25897 0.51 20/20
SCHEMBL33214 SCHEMBL33214 0.52 19/20
SCHEMBL26584 SCHEMBL26584 0.51 19/20
SCHEMBL9107 SCHEMBL9107 0.56 12/20
SCHEMBL8532 SCHEMBL8532 1.00 11/20
SCHEMBL9035 SCHEMBL9035 0.56 10/20
SCHEMBL8632 SCHEMBL8632 0.54 10/20
SCHEMBL8670 SCHEMBL8670 0.57 9/20
SCHEMBL8856 SCHEMBL8856 0.53 9/20
SCHEMBL9273 SCHEMBL9273 0.53 9/20
SCHEMBL8931 SCHEMBL8931 0.51 9/20
SCHEMBL8932 SCHEMBL8932 0.51 9/20
SCHEMBL9163 SCHEMBL9163 0.58 8/20
SCHEMBL8941 SCHEMBL8941 0.54 8/20
SCHEMBL8047 SCHEMBL8047 0.56 7/20

Clinical trials — most relevant to GABRG1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Computational Assessment of GABA Receptor Modulation in PTSD PHASE4RECRUITING
Safety of Ramelteon in Elderly Subjects PHASE4COMPLETED
The Effect of Oral Baclofen and Botulinum Toxin Treatments in Hemiplegic Spasticity on the Nociceptive Flexor Reflex PHASE4COMPLETED
The Effects of Levetiracetam on Alcohol Dependent Subjects PHASE4COMPLETED
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia PHASE3COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia PHASE2COMPLETED
Diazepam Trial in GAD65 Associated Epilepsy PHASE1/PHASE2WITHDRAWN
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia PHASE2COMPLETED
Effects of Direct Transcranial Current Stimulation on Central Neural Pain Processing in Fibromyalgia PHASE1/PHASE2COMPLETED
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome PHASE2RECRUITING
The Use of Glutamic Acid Decarboxylase (GAD) and Gamma-Amino Butyric Acid (GABA) in the Treatment of Type I Diabetes PHASE1COMPLETED
PET Imaging of Brain Peripheral Benzodiazepine Receptors PHASE1COMPLETED
Physiologic Effects of Topiramate on Cognition PHASE1COMPLETED
MEG Study of Acute STX209 Effects in ASD EARLY_PHASE1COMPLETED
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T EARLY_PHASE1UNKNOWN
Cenobamate Efficacy in Individuals With Autoimmune Epilepsy nanENROLLING_BY_INVITATION
GABA Biomarkers in Dravet Syndrome nanRECRUITING
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy nanUNKNOWN
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery. nanCOMPLETED
GABRA2 and the Pharmacokinetics of Risk for Alcoholism (GPRA) nanCOMPLETED
Remifentanil and Remimazolam to Limit Patient Movement nanRECRUITING
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy) nanUNKNOWN
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory nanCOMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain nanUNKNOWN
Assessment of Peripheral GABA Receptors for Local Pain Relief nanUNKNOWN
Effects of Flumazenil on Brain Excitability nanCOMPLETED
Functional Study of Inhibitory Neurotransmission in the Human Epileptic Brain. nanRECRUITING
Effect of Gabapentin on GABA Concentration and Emotional Processing nanCOMPLETED
GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a GABRG1 binder may also engage these)

ProteinNameSimilarity
P23574 — 1.000 P23574 →
Q9R0Y8 — 1.000 Q9R0Y8 →
P22300 — 1.000 P22300 →
P18508 — 0.999 P18508 →
GABRG2 Gamma-aminobutyric acid receptor subunit gamm 0.997 landscape →
P22723 — 0.996 P22723 →
Q5REA1 — 0.995 Q5REA1 →
P21548 — 0.992 P21548 →
P34904 — 0.983 P34904 →
P24045 — 0.962 P24045 →
GABRA6 Gamma-aminobutyric acid receptor subunit alpha-6 0.962 landscape →
P26049 — 0.958 P26049 →
P10064 — 0.958 P10064 →
P30191 — 0.957 P30191 →
P20236 — 0.957 P20236 →
Q90845 — 0.955 Q90845 →
GABRA3 Gamma-aminobutyric acid receptor subunit alpha-3 0.955 landscape →
P16305 — 0.954 P16305 →
P50571 — 0.954 P50571 →
P15431 — 0.954 P15431 →
GABRB1 Gamma-aminobutyric acid receptor subunit beta-1 0.953 landscape →
P27681 — 0.952 P27681 →
P28473 — 0.951 P28473 →
P63137 — 0.950 P63137 →
P08219 — 0.949 P08219 →
GABRB2 Gamma-aminobutyric acid receptor subunit beta-2 0.949 landscape →
P08220 — 0.949 P08220 →
Q5R6B2 — 0.949 Q5R6B2 →
P62812 — 0.948 P62812 →
GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 0.948 landscape →