Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 13/20 | 0.73 |
| ▸ | BRD2 | P25440 | 4/20 | 0.73 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.71 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.71 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.71 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.71 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.71 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.71 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.71 |
| ▸ | SMCHD1 | A6NHR9 | 1/20 | 0.65 |
| ▸ | MYO1G | B0I1T2 | 1/20 | 0.65 |
| ▸ | AIP | O00170 | 1/20 | 0.65 |
| ▸ | AP3B1 | O00203 | 1/20 | 0.65 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.65 |
| ▸ | CDC7 | O00311 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26258758 | 0.92 | BRD4 (0.64) | BRD4BRD2BRD3HDAC1HDAC2 | |
| SCHEMBL14756861 | 0.90 | BRD4 (0.81) | BRD4BRD2BRD3HDAC1HDAC2 | |
| SCHEMBL26258735 | 0.90 | HDAC1 (0.65) | BRD4BRD2BRD3HDAC1HDAC2 | |
| SCHEMBL29377764 | 0.90 | BRD4 (0.81) | BRD4BRD2BRD3HDAC1HDAC2 | |
| SCHEMBL26315418 | 0.90 | HDAC1 (0.64) | BRD4BRD2BRD3HDAC1HDAC2 | |
| SCHEMBL14756264 | 0.89 | BRD4 (0.81) | BRD4BRD2BRD3HDAC1HDAC2 | |
| SCHEMBL26258732 | 0.88 | HDAC1 (0.70) | BRD4BRD2BRD3HDAC1HDAC2 | |
| SCHEMBL26258737 | 0.86 | BRD4 (0.67) | BRD4BRD2BRD3HDAC1HDAC2 | |
| SCHEMBL26258756 | 0.86 | HDAC1 (0.61) | BRD4BRD2BRD3HDAC1HDAC2 | |
| SCHEMBL26258706 | 0.86 | BRD4 (0.79) | BRD4BRD2BRD3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230285570-A1 | THERAPEUTICALLY USEFUL CURE-PRO MOLECULES FOR E3 LIGASE MEDIATED DEGRADATION OF PROTEINS, AND METHODS OF MAKING AND USING THEM | CORNELL UNIVERSITY | 2023-09-14 | — | — | US | disclosed |
| US-20230277553-A1 | THERAPEUTIC COMPOSITION OF CURE-PRO COMPOUNDS FOR TARGETED DEGRADATION OF BET DOMAIN PROTEINS, AND METHODS OF MAKING AND USAGE | CORNELL UNIVERSITY | 2023-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230285570-A1 | THERAPEUTICALLY USEFUL CURE-PRO MOLECULES FOR E3 LIGASE MEDIATED DEGRADATION OF PROTEINS, AND METHODS OF MAKING AND USING THEM | XIAP, CUL4A, CUL1 | BRD4 331/4885BRD2 497/4885BRD3 431/4885 |
| US-20230277553-A1 | THERAPEUTIC COMPOSITION OF CURE-PRO COMPOUNDS FOR TARGETED DEGRADATION OF BET DOMAIN PROTEINS, AND METHODS OF MAKING AND USAGE | BET1, BRD4, PHKB | BRD4 2/4885BRD2 12/4885BRD3 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.