Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30040122 | 0.91 | RAB9A (0.44) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL25400113 | 0.91 | RAB9A (0.44) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL26262078 | 0.86 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL30041546 | 0.86 | RAB9A (0.41) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL26260731 | 0.86 | RAB9A (0.41) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL23618342 | 0.83 | IDH2 (0.41) | PDE10AHDAC1HDAC8HDAC6GRM4 | |
| SCHEMBL30040258 | 0.83 | IDH2 (0.41) | PDE10AHDAC1HDAC8HDAC6GRM4 | |
| SCHEMBL26260736 | 0.83 | SMN1; SMN2 (0.45) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL30041208 | 0.83 | SMN1; SMN2 (0.45) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL30041878 | 0.82 | ABCB1 (0.43) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4085054-B1 | NEW PQSR INVERSE AGONISTS | HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) | 2025-02-19 | — | — | EP | disclosed |
| US-20230286942-A1 | NEW PqsR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2023-09-14 | — | — | US | disclosed |
| EP-4085054-A1 | NEW PQSR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2022-11-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230286942-A1 | NEW PqsR INVERSE AGONISTS | QRFPR, P2RY11, GPR55 | NPC1 4374/4885RAB9A 991/4885SMN1; SMN2 4177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.