Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 5/20 | 0.51 |
| ▸ | GFER | P55789 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2626701 | 1.00 | ALDH1A1 (0.59) | ALDH1A1GAAGFERKMT2ASCN9A | |
| SCHEMBL10310857 | 1.00 | ALDH1A1 (0.59) | ALDH1A1GAAGFERKMT2ASCN9A | |
| SCHEMBL1576404 | 0.89 | KMT2A (0.48) | ALDH1A1KMT2ASCN9ALMNASCN1B | |
| SCHEMBL12709026 | 0.89 | KMT2A (0.48) | ALDH1A1KMT2ASCN9ALMNASCN1B | |
| SCHEMBL2626698 | 0.89 | KMT2A (0.48) | ALDH1A1KMT2ASCN9ALMNASCN1B | |
| SCHEMBL2625918 | 0.86 | SCN9A (0.52) | ALDH1A1KMT2ASCN9AMEN1LMNA | |
| SCHEMBL2626679 | 0.86 | SCN9A (0.52) | ALDH1A1KMT2ASCN9AMEN1LMNA | |
| SCHEMBL2626065 | 0.81 | KMT2A (0.52) | ALDH1A1KMT2ASCN9AMEN1LMNA | |
| SCHEMBL1576529 | 0.81 | KMT2A (0.52) | ALDH1A1KMT2ASCN9AMEN1LMNA | |
| SCHEMBL1576703 | 0.81 | KMT2A (0.52) | ALDH1A1KMT2ASCN9AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163720-B2 | Pyrrolidinyl phenyl sulphonamides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163720-B2 | Pyrrolidinyl phenyl sulphonamides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-24 | — | — | US | disclosed |