Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 15/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 9/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1576404 | 1.00 | KMT2A (0.48) | KMT2ASCN9ALMNASMN1; SMN2SCN3A | |
| SCHEMBL12709026 | 1.00 | KMT2A (0.48) | KMT2ASCN9ALMNASMN1; SMN2SCN3A | |
| SCHEMBL2626536 | 0.89 | ALDH1A1 (0.59) | KMT2ASCN9ALMNAALDH1A1SCN1B | |
| SCHEMBL2626701 | 0.89 | ALDH1A1 (0.59) | KMT2ASCN9ALMNAALDH1A1SCN1B | |
| SCHEMBL10310857 | 0.89 | ALDH1A1 (0.59) | KMT2ASCN9ALMNAALDH1A1SCN1B | |
| SCHEMBL1576275 | 0.86 | SCN9A (0.52) | KMT2ASCN9ALMNASMN1; SMN2SCN5A | |
| SCHEMBL1576868 | 0.86 | SCN9A (0.52) | KMT2ASCN9ALMNASMN1; SMN2SCN5A | |
| SCHEMBL1576272 | 0.86 | SCN9A (0.52) | KMT2ASCN9ALMNASMN1; SMN2SCN5A | |
| SCHEMBL1576480 | 0.81 | SCN9A (0.53) | KMT2ASCN9ALMNASMN1; SMN2SCN5A | |
| SCHEMBL12710655 | 0.81 | SCN9A (0.53) | KMT2ASCN9ALMNASMN1; SMN2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163720-B2 | Pyrrolidinyl phenyl sulphonamides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163720-B2 | Pyrrolidinyl phenyl sulphonamides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-24 | — | — | US | disclosed |